ID A0A0E3SER5_9EURY Unreviewed; 955 AA.
AC A0A0E3SER5;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Lead, cadmium, zinc and mercury transporting ATPase {ECO:0000313|EMBL:AKB79481.1};
DE EC=3.6.3.3 {ECO:0000313|EMBL:AKB79481.1};
DE EC=3.6.3.4 {ECO:0000313|EMBL:AKB79481.1};
DE EC=3.6.3.5 {ECO:0000313|EMBL:AKB79481.1};
GN ORFNames=MSHOH_2998 {ECO:0000313|EMBL:AKB79481.1};
OS Methanosarcina horonobensis HB-1 = JCM 15518.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434110 {ECO:0000313|EMBL:AKB79481.1, ECO:0000313|Proteomes:UP000033101};
RN [1] {ECO:0000313|EMBL:AKB79481.1, ECO:0000313|Proteomes:UP000033101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HB-1 {ECO:0000313|EMBL:AKB79481.1,
RC ECO:0000313|Proteomes:UP000033101};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009516; AKB79481.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0E3SER5; -.
DR STRING; 1434110.MSHOH_2998; -.
DR KEGG; mhor:MSHOH_2998; -.
DR PATRIC; fig|1434110.4.peg.3864; -.
DR HOGENOM; CLU_001771_0_3_2; -.
DR Proteomes; UP000033101; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR CDD; cd00371; HMA; 3.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 3.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR NCBIfam; TIGR00003; copper ion binding protein; 3.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 3.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00943; CUATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 2.
DR PROSITE; PS50846; HMA_2; 3.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Hydrolase {ECO:0000313|EMBL:AKB79481.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 899..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..58
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 134..200
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 202..268
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 54..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 102541 MW; CD077EB877DE75B3 CRC64;
MTCGHCQKRV ADAISSLDGV KSVDVNLEAE SATVNFDPDK LSLEDIKEAV RKAGYSTERE
EATTEGYEEE VQAENSEPAL EKEKAGLLSE PVDRVSEEVK EGVVESSQAC PLTEPCIAAE
KEAVRISSQK PGSKEITLGV SGMTCSACAL NIEKILKKKE GVDSVAVNLE LGRAQVSFDP
SMVSPKEIEE AIESIGYKVE KDKVTLNIQG MSCASCASNI EKILYKTEGV ISASVNLPLE
KAVVEFDSAR ISVREIIAAI QGIGYGASVQ AETVEYEDRE QMSRDAEIRR QRNNLIIALV
LGIPIALGNM SMAFPFLAFV PEILTEPVVL FILSTLVLLF PGRQFFVGTF KGFKHGVTDM
NLLIAAGTGS AYLISVAATF LDLGPGYDVL YYDTVALLIL FIVFGRYLEA RARGRTSEAI
RKLMGLRAKT SRILVDGEEK EVPVEEVVVG DIVVVRPGEK IPVDGIVVQG SSAVDESMIT
GESIPVEKSQ GDTVIGATLN KTGSFRFRAT KVGADTALAQ IIRLVESAQT TKAPIQRIAD
VFAGNFIVAV HIIALVAFFF WFFIGYWRYG VGESIALGGI SPFLFSLLIA ITVLVISCPC
AVGLATPAAI MVGTGKGAEN GILIKGGEAL ERAHKLDTIV FDKTGTLTEG TPKLTDVFAV
SGREENEVLF IAATAERGSE HPLGEAIVRG ADERKIDLAE AKNFRSIPGK GIEAYLEDRK
ILLGTRKLME ENSISFEGLE TQMRKFEEQG KTAMLVALGN EAVGLVAVAD TLKENSKEAV
DTLKKMNIEV VMITGDNAIT AGAIAGEVGI PRVLAEVLPE DKANEIKKLQ KEGKLVGMVG
DGINDAPALI QSDVGIAMGA GTDVAMESAK IVLIKNDPRD VVAALKLSRL TINKIKQNLV
WAFGYNTIGI PIAAGILYPF FLRIMITPEL AAAFMALSSV SVTTNSLLMK RSRIK
//
