ID A0A0E3SMR1_METBA Unreviewed; 399 AA.
AC A0A0E3SMR1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:AKB82268.1};
GN ORFNames=MSBR3_1690 {ECO:0000313|EMBL:AKB82268.1};
OS Methanosarcina barkeri 3.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434107 {ECO:0000313|EMBL:AKB82268.1, ECO:0000313|Proteomes:UP000033066};
RN [1] {ECO:0000313|EMBL:AKB82268.1, ECO:0000313|Proteomes:UP000033066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3 {ECO:0000313|EMBL:AKB82268.1,
RC ECO:0000313|Proteomes:UP000033066};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP009517; AKB82268.1; -; Genomic_DNA.
DR RefSeq; WP_048107660.1; NZ_CP009517.1.
DR AlphaFoldDB; A0A0E3SMR1; -.
DR STRING; 1434107.MSBR3_1690; -.
DR GeneID; 24789236; -.
DR KEGG; mbak:MSBR3_1690; -.
DR PATRIC; fig|1434107.4.peg.2182; -.
DR HOGENOM; CLU_009273_4_0_2; -.
DR OrthoDB; 30736at2157; -.
DR Proteomes; UP000033066; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR030894; Ahb_Proteobacteria.
DR InterPro; IPR034479; AhbC-like.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034480; Heme_carboxy_lyase-like.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04546; rSAM_ahbC_deAc; 1.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR SFLD; SFLDF00543; alternative_heme_biosynthesis; 1.
DR SFLD; SFLDG01385; heme_carboxy_lyase_like; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 36..253
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 399 AA; 45047 MW; 618BC6CD67B660E8 CRC64;
MIGISKLYCG TVEPSDALRY GRESKKLPSH LLQFSKDKKP VVVWNMTRRC NLKCVHCYAQ
AKDIEFENEL STEEGKALID DLASFGSPVI LFSGGEPTLR KDLPELAAYA REKGMRAVIS
TNGTLIDRDM AKKLKEVGLS YVGVSLDGIR ETNDKFRGVK GAFDAALRGL HNCQEEGIKV
GLRFTINKQN VRDIPAIFDL LEEENIPRIC FYHLVYAGRG SKMVKEDLSL EESRQAVDLI
LERTRKLHEK GFPAEVLTVD NHCDGPYLYM KLLKENPERA AEVFELLSMN QGNSSGIGIG
CVSWDGAVHA DQFWRHYSFG NIRERPFSEI WTDLSDKLMA GLKNRKPLIK VNGDRCARCN
WLDVCNGNFR VRAEAVYGNV WADDPACYLT KEEIGYYKA
//
