ID A0A0E3ULG0_9GAMM Unreviewed; 790 AA.
AC A0A0E3ULG0;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AKC85446.1};
GN ORFNames=WQ53_00300 {ECO:0000313|EMBL:AKC85446.1};
OS Pseudoxanthomonas suwonensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Pseudoxanthomonas.
OX NCBI_TaxID=314722 {ECO:0000313|EMBL:AKC85446.1, ECO:0000313|Proteomes:UP000033067};
RN [1] {ECO:0000313|EMBL:AKC85446.1, ECO:0000313|Proteomes:UP000033067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J1 {ECO:0000313|EMBL:AKC85446.1,
RC ECO:0000313|Proteomes:UP000033067};
RX PubMed=26067962;
RA Hou L., Jiang J., Xu Z., Zhou Y., Leung F.C.;
RT "Complete Genome Sequence of Pseudoxanthomonas suwonensis Strain J1, a
RT Cellulose-Degrading Bacterium Isolated from Leaf- and Wood-Enriched Soil.";
RL Genome Announc. 3:e00614-15(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP011144; AKC85446.1; -; Genomic_DNA.
DR RefSeq; WP_052629484.1; NZ_CP011144.1.
DR AlphaFoldDB; A0A0E3ULG0; -.
DR KEGG; psuw:WQ53_00300; -.
DR PATRIC; fig|314722.6.peg.65; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000033067; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000033067}.
FT DOMAIN 10..192
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 790 AA; 85652 MW; 7E1FB1859A7DBA4B CRC64;
MSEKLLVRRA AVLGAGVMGA QIAAHLTNAG VDTVLFDLAA KEGPADGVVL KALAHLGKLS
PAPLAGKSLA EAITPANYDT GLEQLKDCDL IIEAIAERMD WKQDLYRKIA PFVADHAVLA
SNTSGLGVNR LAEVLPEQLR HRFCGVHFFN PPRYMHLAEL IPARTTDKAV LEGLETFLTT
QLGKGVVYAK DTPNFIGNRI GVFSILSVIH HTRQFGLGFD EVDALTGPLV GRPKSATYRT
SDVVGLDTMA HVIKTMADTL PNDPWHSYFQ SPDWLAALVG KGALGQKAGA GIFRKVGKDI
VVLDLEKQDY RAADRKAADE VVEILKIRNP AEKFARLRES AHPQAQFLWA AFRDLFHYSA
YHLADIAQTA RDVDLAIRWG YGWSLGPFET WQAAGWKQVA QWIADDIAAG KTMSDAPLPA
WVLDGRDDVH AAEGSYSPAQ DALVPRSSLP VYRRQRFPDP LLGERFDPGQ TVFENDGVRL
WHDGDGIAVV SFKTKMNTVS DQVLDGLQEA IAIAERDFQG LVIWQQKEPF SAGADLAGAL
GLLQAGKVDA FEAMVANFQR TSQRIKYALV PVVAAVRGLA LGGGCEFQMH AARTVAHLES
YIGLVEAGVG LLPAGGGLKE LAVRASRAAG PGGDVFAELK KTFEAVAMAK VSASALEAKE
LGLLRADDTI VFNAFELLHV AKAQARALAE AGYRPPLPAR RVQVAGDVGV ATFRMLLVNM
LEGRFISPYD DEIATRIATV LCGGEVDRGA LVDEEWLIGL ERKHFVELAQ QEKTQARIGH
MLKTGKPLRN
//
