UniProt: A0A0E3UVC6

Database: UniProt
Entry: A0A0E3UVC6_9FUSO

LinkDB:  A0A0E3UVC6_9FUSO 
Original site:  A0A0E3UVC6_9FUSO

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (18)   

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ID   A0A0E3UVC6_9FUSO        Unreviewed;       463 AA.
AC   A0A0E3UVC6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   ORFNames=VC03_04185 {ECO:0000313|EMBL:AKC96153.1};
OS   Sneathia vaginalis.
OC   Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC   Sneathia.
OX   NCBI_TaxID=187101 {ECO:0000313|EMBL:AKC96153.1, ECO:0000313|Proteomes:UP000033103};
RN   [1] {ECO:0000313|EMBL:AKC96153.1, ECO:0000313|Proteomes:UP000033103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN35 {ECO:0000313|EMBL:AKC96153.1,
RC   ECO:0000313|Proteomes:UP000033103};
RX   PubMed=23281612;
RG   Vaginal Microbiome Consortium (additional members);
RA   Harwich M.D.Jr., Serrano M.G., Fettweis J.M., Alves J.M., Reimers M.A.,
RA   Buck G.A., Jefferson K.K.;
RT   "Genomic sequence analysis and characterization of Sneathia amnii sp.
RT   nov.";
RL   BMC Genomics 13:S4-S4(2012).
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362011}.
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DR   EMBL; CP011280; AKC96153.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0E3UVC6; -.
DR   STRING; 187101.VC03_04185; -.
DR   KEGG; sns:VC03_04185; -.
DR   PATRIC; fig|1069640.6.peg.829; -.
DR   HOGENOM; CLU_037408_1_1_0; -.
DR   Proteomes; UP000033103; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033103};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        371..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        397..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        433..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          215..272
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  51620 MW;  A259CCAB19794B0C CRC64;
     MKARLSDNYD EKENEEEKVS CEEIADEIRN IGTEEELHEY LEEHHDVDIA ESFEEFEDDE
     DILRILNALD YEEKANVIEE ADEKIQKKIV EILPEDEVIE IFSHMSPDDI VDILGYINFQ
     KRKSLLDSMK RSDANKLREL LGYETDSAGG IMTTQFIAFK KNLKMKDILE KIKIIGPKTE
     YIETIFVLDE NGALMGEADL RDILCSSDDT LLSEITEENF KYVNPKDDQE EVALLVSKYS
     LKVVPVVSDK MALMGIITID DVVDVIQEEH TEDMLKLAGT GDDEDIYTSL YESTKKRLPW
     LLINLLTAFL ASFTVGLFQN TIDKVVALAV TMPIVSGMGG NAGTQALAVT IRSIALGEYD
     GNDNLEISIK YIVLGFINGL LIGIVCALII SLAFQNIYLG VVILLSMIGN CIIACLVGYL
     IPIGLQAMNI DPAMASAVIL TTVTDVCGFF LFLGLATMFI TKL
//

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