ID   A0A0E3WW89_METBA        Unreviewed;       283 AA.
AC   A0A0E3WW89;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=2-oxoglutarate oxidoreductase, beta subunit {ECO:0000313|EMBL:AKB81710.1};
DE            EC=1.2.7.3 {ECO:0000313|EMBL:AKB81710.1};
GN   ORFNames=MSBR3_1132 {ECO:0000313|EMBL:AKB81710.1};
OS   Methanosarcina barkeri 3.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1434107 {ECO:0000313|EMBL:AKB81710.1, ECO:0000313|Proteomes:UP000033066};
RN   [1] {ECO:0000313|EMBL:AKB81710.1, ECO:0000313|Proteomes:UP000033066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3 {ECO:0000313|EMBL:AKB81710.1,
RC   ECO:0000313|Proteomes:UP000033066};
RA   Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA   Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT   "Methanogenic archaea and the global carbon cycle.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP009517; AKB81710.1; -; Genomic_DNA.
DR   RefSeq; WP_048107156.1; NZ_CP009517.1.
DR   AlphaFoldDB; A0A0E3WW89; -.
DR   STRING; 1434107.MSBR3_1132; -.
DR   GeneID; 24788643; -.
DR   KEGG; mbak:MSBR3_1132; -.
DR   PATRIC; fig|1434107.4.peg.1493; -.
DR   HOGENOM; CLU_048564_0_0_2; -.
DR   OrthoDB; 30755at2157; -.
DR   Proteomes; UP000033066; Chromosome.
DR   GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd03375; TPP_OGFOR; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR011896; OFOB.
DR   InterPro; IPR032686; PFO_beta_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   NCBIfam; TIGR02177; PorB_KorB; 1.
DR   PANTHER; PTHR48084:SF4; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB; 1.
DR   PANTHER; PTHR48084; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED; 1.
DR   Pfam; PF12367; PFO_beta_C; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AKB81710.1}.
FT   DOMAIN          53..194
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   DOMAIN          198..261
FT                   /note="Pyruvate ferredoxin oxidoreductase beta subunit C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12367"
SQ   SEQUENCE   283 AA;  31745 MW;  5F603E1FB6F31CBA CRC64;
     MPTSEDYQGQ VPAWCPGCGN FNILSTVKEA LVELGIEPWE VLVVSGIGQA GKLPHYMRCH
     TFNGLHGRTL PVATAAKLAN HSLHVIAVAG DGDCYGEGGN HFLHTIRRNP NITLLVHDNQ
     IYGLTKGQAS PTTAQKTHTK IQPYGVLAEQ MNPLALAISQ DCSFVARGFA GDQGYLKELM
     KAAITHKGFS LLDILQPCVT FNKINTFKWY RDRVYKLEEE YDPSDRLKAF EKSLEWGDKI
     PNGILYKNER ETLEEGMPTI QEEPLVRQKF SIKDVKHEIE KFY
//