ID A0A0E3XSZ2_MYCCH Unreviewed; 361 AA.
AC A0A0E3XSZ2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245};
DE AltName: Full=Membrane protein YidC {ECO:0000256|ARBA:ARBA00031538};
GN Name=yidC {ECO:0000313|EMBL:MBF9524032.1};
GN ORFNames=BKG82_12445 {ECO:0000313|EMBL:OHU58370.1}, BKG84_11755
GN {ECO:0000313|EMBL:OHU78963.1}, GR01_23775
GN {ECO:0000313|EMBL:AKC40987.1}, HA136_24075
GN {ECO:0000313|EMBL:MBF9524032.1};
OS Mycobacteroides chelonae (Mycobacterium chelonae).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides.
OX NCBI_TaxID=1774 {ECO:0000313|EMBL:AKC40987.1, ECO:0000313|Proteomes:UP000033056};
RN [1] {ECO:0000313|EMBL:AKC40987.1, ECO:0000313|Proteomes:UP000033056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35752 {ECO:0000313|EMBL:AKC40987.1,
RC ECO:0000313|Proteomes:UP000033056};
RX PubMed=26021923;
RA Hasan N.A., Davidson R.M., de Moura V.C., Garcia B.J., Reynolds P.R.,
RA Epperson L.E., Farias-Hesson E., DeGroote M.A., Jackson M., Strong M.;
RT "Draft Genome Sequence of Mycobacterium chelonae Type Strain ATCC 35752.";
RL Genome Announc. 3:e00536-15(2015).
RN [2] {ECO:0000313|Proteomes:UP000179441, ECO:0000313|Proteomes:UP000180043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=15515 {ECO:0000313|EMBL:OHU58370.1,
RC ECO:0000313|Proteomes:UP000180043}, and 15518
RC {ECO:0000313|EMBL:OHU78963.1, ECO:0000313|Proteomes:UP000179441};
RA Fogelson S.B., Camus A.C., Lorenz W., Vasireddy R., Vasireddy S., Smith T.,
RA Brown-Elliott B.A., Wallace R.J.Jr., Hasan N.A., Reischl U., Sanchez S.;
RT "Evaluation of Human, Veterinary and Environmental Mycobacterium chelonae
RT Isolates by Core Genome Phylogenomic Analysis, Targeted Gene Comparison,
RT and Anti-microbial Susceptibility Patterns: A Tale of Mistaken
RT Identities.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MBF9524032.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Myco6 {ECO:0000313|EMBL:MBF9524032.1};
RX PubMed=33166284;
RA Gu C.H., Zhao C., Hofstaedter C., Tebas P., Glaser L., Baldassano R.,
RA Bittinger K., Mattei L.M., Bushman F.D.;
RT "Investigating hospital Mycobacterium chelonae infection using whole genome
RT sequencing and hybrid assembly.";
RL PLoS ONE 15:0-e0236533(2020).
RN [4] {ECO:0000313|EMBL:MBF9524032.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Myco6 {ECO:0000313|EMBL:MBF9524032.1};
RA Gu C.H., Zhao C., Bushman F.D.;
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|ARBA:ARBA00025034}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration.
CC {ECO:0000256|ARBA:ARBA00026028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527}.
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DR EMBL; CP010946; AKC40987.1; -; Genomic_DNA.
DR EMBL; JAAOOS010000002; MBF9524032.1; -; Genomic_DNA.
DR EMBL; MLIQ01000013; OHU58370.1; -; Genomic_DNA.
DR EMBL; MLIS01000001; OHU78963.1; -; Genomic_DNA.
DR RefSeq; WP_030097693.1; NZ_MLIU01000028.1.
DR GeneID; 31682391; -.
DR PATRIC; fig|1774.35.peg.4835; -.
DR HOGENOM; CLU_036138_3_0_11; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000033056; Chromosome.
DR Proteomes; UP000179441; Unassembled WGS sequence.
DR Proteomes; UP000180043; Unassembled WGS sequence.
DR Proteomes; UP000699007; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT TRANSMEM 9..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..270
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 281..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 40410 MW; 21FE97C6929C7069 CRC64;
MFDWFSLGFI YYPVSAIMWV WYKLFAYLLG PKNFFAWALS VMFLVFTLRA ILYKPFVRQI
RTTRQMQELQ PQIKALQKKY KNDRQRMALE MQKLQREHGF NPILGCLPML AQIPVFLGLF
HVLRSFNRTT GGFGQVHMSV EANRATGNYI FSAGDVANFL DANLFGAPLG ATMIQTTGLD
AFTEFNRWAV AGVSIPLMVI AGIATYFNSR ASIARQSPEA QANPQTQIMN RLALYVFPLG
VVVGGPFLPI AIILYWVSNN IWTFGQQHYV FNHIAKEEEE KKQADLERRA ANAPKPGAKP
TRGGKNQPAK QADESDSTEI VESGGTDEDT GGQASPDSTN GSGTTSRTPK PGARPDRRRK
R
//
