ID A0A0E3ZCI6_9FUSO Unreviewed; 549 AA.
AC A0A0E3ZCI6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=PTS mannose transporter subunit IIAB {ECO:0000313|EMBL:AKC95687.1};
GN ORFNames=VC03_04105 {ECO:0000313|EMBL:AKC95687.1};
OS Sneathia vaginalis.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC Sneathia.
OX NCBI_TaxID=187101 {ECO:0000313|EMBL:AKC95687.1, ECO:0000313|Proteomes:UP000033103};
RN [1] {ECO:0000313|EMBL:AKC95687.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN35 {ECO:0000313|EMBL:AKC95687.1};
RX PubMed=23281612;
RG Vaginal Microbiome Consortium (additional members);
RA Harwich M.D.Jr., Serrano M.G., Fettweis J.M., Alves J.M., Reimers M.A.,
RA Buck G.A., Jefferson K.K.;
RT "Genomic sequence analysis and characterization of Sneathia amnii sp.
RT nov.";
RL BMC Genomics 13:S4-S4(2012).
RN [2] {ECO:0000313|EMBL:AKC95687.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SN35 {ECO:0000313|EMBL:AKC95687.1};
RG Vaginal Microbiome Consortium;
RA Harwich M.D.Jr., Serrano M.G., Fettweis J.M., Alves J.M.P., Reimers M.A.,
RA Buck G.A., Jefferson K.K.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP011280; AKC95687.1; -; Genomic_DNA.
DR RefSeq; WP_046328793.1; NZ_CP011280.1.
DR AlphaFoldDB; A0A0E3ZCI6; -.
DR STRING; 187101.VC03_04105; -.
DR KEGG; sns:VC03_04105; -.
DR PATRIC; fig|1069640.6.peg.813; -.
DR HOGENOM; CLU_012312_1_0_0; -.
DR OrthoDB; 9764327at2; -.
DR Proteomes; UP000033103; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1360.60; Glucose permease domain IIB; 1.
DR InterPro; IPR036878; Glu_permease_IIB.
DR InterPro; IPR018113; PTrfase_EIIB_Cys.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013013; PTS_EIIC_1.
DR InterPro; IPR001996; PTS_IIB_1.
DR NCBIfam; TIGR00826; EIIB_glc; 1.
DR PANTHER; PTHR30009; CYTOCHROME C-TYPE SYNTHESIS PROTEIN AND PTS TRANSMEMBRANE COMPONENT; 1.
DR PANTHER; PTHR30009:SF20; PTS SYSTEM GLUCOSE-SPECIFIC EIICB COMPONENT-RELATED; 1.
DR Pfam; PF00367; PTS_EIIB; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR SUPFAM; SSF55604; Glucose permease domain IIB; 1.
DR PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000033103};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..432
FT /note="PTS EIIC type-1"
FT /evidence="ECO:0000259|PROSITE:PS51103"
FT DOMAIN 469..549
FT /note="PTS EIIB type-1"
FT /evidence="ECO:0000259|PROSITE:PS51098"
FT ACT_SITE 491
FT /note="Phosphocysteine intermediate; for EIIB activity"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
SQ SEQUENCE 549 AA; 60132 MW; E570B4872ECD9098 CRC64;
MERNKVIVAF EKFGRSFLLP VSVLPAAGIL KGIGAAFTNP STVKMYPFLG VKGLQIFMKL
LVTLGDVAFK NLPLMFAVGV CVGLAKKEKG SAALSAVLGF LSFHYILNFL LKTTGTLVVA
DGLTKAQVSQ LMAQSMQTKV LGIQTMDLNV FGGLIVGVVA YFVHKKAITI QLPQVIGFFS
GPRLVPILIM PVMALVSLIV FIIWPSVQNV INIISVLILK SGYIGTFLYA LAERFLLPFG
LHHGLNWPIR TTELGGIFNV NGKTVYGTIN AYMAAISTPN GPIDPNITRF SSGKFVYNMF
GLPGAALAMY KTAKPKNKKI VGSLLLAAAG TSFLTGITEP LEFTFLFVAP MLYAVHAVLA
GITLLSLHAL GAAFLTPTGH GLINYIIYGV LQGTRTKWYL LPITGVVCFI VYYFVFKFMI
TKFDYKTPGR EGDIEDIHIS TKEEARSKYG LKTLKDEMRE EKQEKMSTHD QALGLIECYG
GRENIVTVDA CITRLRIDVK DKAKVDKKRI KEEYHAMGVS ENGMQVQSIY GAHAQTLKME
IIDILGIED
//
