ID A0A0E4G9L3_9FIRM Unreviewed; 429 AA.
AC A0A0E4G9L3;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Thiolase {ECO:0000313|EMBL:CFX17230.1};
GN ORFNames=706 {ECO:0000313|EMBL:CFX17230.1};
OS Syntrophomonas zehnderi OL-4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Syntrophomonadaceae;
OC Syntrophomonas.
OX NCBI_TaxID=690567 {ECO:0000313|EMBL:CFX17230.1, ECO:0000313|Proteomes:UP000045545};
RN [1] {ECO:0000313|EMBL:CFX17230.1, ECO:0000313|Proteomes:UP000045545}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OL-4 {ECO:0000313|EMBL:CFX17230.1,
RC ECO:0000313|Proteomes:UP000045545};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CGIH01000009; CFX17230.1; -; Genomic_DNA.
DR RefSeq; WP_046495845.1; NZ_CGIH01000009.1.
DR AlphaFoldDB; A0A0E4G9L3; -.
DR STRING; 690567.706; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000045545; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000045545};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 4..294
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 303..426
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 97
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 381
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 414
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 429 AA; 45598 MW; 22B373FF4ED5B946 CRC64;
MKDVFVVEAA RTAVARAGKQ SWFTNVRADE LSAIVFKELR KRIGCEDKAK QAELIDDVVW
AATANAFMEQ GLNQGRLAWI LSDGSYDVPG CTVDRFCASG LNSISFATST MMAGWGGDVQ
IAGGAQHMSH IPMGAGADVH PDLGNYMTLA AINMGYTAEI VARRFNVGRE AQDQLAMESH
LKCAAAQAAN GGLGKAKDAI IPIMAKVPAK SAKGEVKRDG AYVATDHLAK AAAEKGEELV
EFCVARDQGV RPETTMESLA AMAPVFMQDE QATVTAGNSS QINDAAAGVV LATAEGAKAL
GKKPVMKLLN FAVIGLEPDI MGIGPVLAIP KVLKRAGMTQ DQIGLWEINE AFASQSVYCR
ETLGLPKEKV NVWGSGISIG HPLACTGARI ACDIFYMFQD PDYADVEYIV ESMCIGHGHG
AAAIWQRVK
//
