ID A0A0E7SMU6_MYCTX Unreviewed; 459 AA.
AC A0A0E7SMU6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Resolvase {ECO:0000313|EMBL:QGK80111.1};
DE SubName: Full=Transposase {ECO:0000313|EMBL:CKR83374.1};
GN ORFNames=A4S10_03107 {ECO:0000313|EMBL:OMH60922.1}, ERS007665_01771
GN {ECO:0000313|EMBL:CNU87244.1}, ERS027659_01712
GN {ECO:0000313|EMBL:CKR55646.1}, ERS027661_02182
GN {ECO:0000313|EMBL:CKR83374.1}, ERS053720_02757
GN {ECO:0000313|EMBL:CFH87644.1}, GJE03_15620
GN {ECO:0000313|EMBL:QGK80111.1}, SAMEA2683035_02284
GN {ECO:0000313|EMBL:SGH90625.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CKR83374.1, ECO:0000313|Proteomes:UP000049023};
RN [1] {ECO:0000313|Proteomes:UP000045274, ECO:0000313|Proteomes:UP000049023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH90625.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 185
RC {ECO:0000313|EMBL:CKR55646.1, ECO:0000313|Proteomes:UP000050164}, Bir
RC 187 {ECO:0000313|EMBL:CKR83374.1, ECO:0000313|Proteomes:UP000049023},
RC and D00700688 {ECO:0000313|EMBL:CNU87244.1,
RC ECO:0000313|Proteomes:UP000045274};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CFH87644.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH87644.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH60922.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH60922.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH60922.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH60922.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QGK80111.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK80111.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transposase 35
CC family. {ECO:0000256|ARBA:ARBA00008761}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the transposase 2
CC family. {ECO:0000256|ARBA:ARBA00011044}.
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DR EMBL; CFSW01000017; CFH87644.1; -; Genomic_DNA.
DR EMBL; CNFT01000340; CKR55646.1; -; Genomic_DNA.
DR EMBL; CNFU01000440; CKR83374.1; -; Genomic_DNA.
DR EMBL; CQPW01000316; CNU87244.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH60922.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK80111.1; -; Genomic_DNA.
DR EMBL; FPTZ01000015; SGH90625.1; -; Genomic_DNA.
DR RefSeq; WP_003415037.1; NZ_WUCS01000004.1.
DR PATRIC; fig|1773.206.peg.1431; -.
DR OMA; WYEMHRQ; -.
DR Proteomes; UP000045274; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR InterPro; IPR010095; Cas12f1-like_TNB.
DR InterPro; IPR001959; Transposase.
DR InterPro; IPR021027; Transposase_put_HTH.
DR NCBIfam; NF040570; guided_TnpB; 1.
DR NCBIfam; NF038280; IS607_TnpB; 1.
DR PANTHER; PTHR30405:SF20; RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED; 1.
DR PANTHER; PTHR30405; TRANSPOSASE; 1.
DR Pfam; PF12323; HTH_OrfB_IS605; 1.
DR Pfam; PF01385; OrfB_IS605; 1.
DR Pfam; PF07282; OrfB_Zn_ribbon; 1.
PE 3: Inferred from homology;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Transposition {ECO:0000256|ARBA:ARBA00022578};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 13..48
FT /note="Transposase putative helix-turn-helix"
FT /evidence="ECO:0000259|Pfam:PF12323"
FT DOMAIN 203..321
FT /note="Probable transposase IS891/IS1136/IS1341"
FT /evidence="ECO:0000259|Pfam:PF01385"
FT DOMAIN 345..407
FT /note="Cas12f1-like TNB"
FT /evidence="ECO:0000259|Pfam:PF07282"
FT REGION 419..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 51407 MW; 75DDF40247A4E865 CRC64;
MPKFEVPDGW TVQAFRFTLD PTEDQAKALA RHFGARRKAY NWTVATLKAD IQAWHASGTV
TAKPSLRVLR KRWNTVKDDV CVNTETGVAW WPECSKEAYA DGIAGAVEAY WNWQTSRAGK
RAGKRVGFPR FKRKGRDQDR VSFTTGAMRV EPDRRHLTLP VIGTVRTHEN TRRIERLIKA
GRARVLAISV RRNGTRLDAS VRVLVQRPQQ PKVVHPGSRV GVDVGVRRLA TVATADGTAI
EQVENPRPLG AALRELRHVC RARSRCTKGS RRYRERTTQI SRLHRRVNDV RTHHLHVLTT
RLAQTHGRIV VEGLDATEML RQKGLPGARA RRRGLSDAAL GTPRRHLSYK TVWYGSALVV
ADRWFPSSKT CHACRHVQDI GWDEQWQCDR CSVVHQRDDC AAINLARYEE TSSIVGPVGA
AVKRGADRKT GPRPAGGCEA RKGSSPKAAE QPRDGVQVA
//
