ID   A0A0E9MP39_9SPHN        Unreviewed;       692 AA.
AC   A0A0E9MP39;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=SCH01S_28_00600 {ECO:0000313|EMBL:GAO39201.1};
OS   Sphingomonas changbaiensis NBRC 104936.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1219043 {ECO:0000313|EMBL:GAO39201.1, ECO:0000313|Proteomes:UP000033202};
RN   [1] {ECO:0000313|EMBL:GAO39201.1, ECO:0000313|Proteomes:UP000033202}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 104936 {ECO:0000313|EMBL:GAO39201.1,
RC   ECO:0000313|Proteomes:UP000033202};
RA   Katano-Makiyama Y., Hosoyama A., Hashimoto M., Noguchi M., Tsuchikane K.,
RA   Ohji S., Yamazoe A., Ichikawa N., Kimura A., Fujita N.;
RT   "Whole genome shotgun sequence of Sphingomonas changbaiensis NBRC 104936.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAO39201.1}.
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DR   EMBL; BBWU01000028; GAO39201.1; -; Genomic_DNA.
DR   RefSeq; WP_052733823.1; NZ_BBWU01000028.1.
DR   AlphaFoldDB; A0A0E9MP39; -.
DR   STRING; 1219043.SCH01S_28_00600; -.
DR   OrthoDB; 7308181at2; -.
DR   Proteomes; UP000033202; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR015032; ThsB__TIR-like_domain.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF08937; ThsB_TIR; 1.
DR   Pfam; PF13424; TPR_12; 2.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50104; TIR; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033202};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        221..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..197
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REPEAT          350..383
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  76873 MW;  ECB59C5F3A27D9C3 CRC64;
     MRRHDRRSVG VAQNPAPGAE TVSARRVVSW HRTLFDQETT LRYSAFISYS HADERWARWL
     HSAIETYRLP KRLIGREGPF GPLSSRLPHV FRDRDELASS SDLAEEIRTA LAESANLIVI
     CSPAAARSRW VNEEIRSFIA LGRAAHIFCL IVDGEPHAAD PAEECFPPAL FEDGHLEPLA
     SDVRPGGDGK KAARLKILAG LLGVGFDELR QRDAARRQHQ LTIIAAASTL GLIFTAALAV
     FAFLSRSEAI RERDIANRKT MTAERTVSFV KSLFEVSDPS EARGQTITAR EILDRGAREI
     RTGLQNEPAV KAELGTTLGE VYSELGLYRE GDQLIREMAG IRHNDTATRT RQLLALADAQ
     TRQADYDAAI RSYNQALRLA RDRRQPRQDL VPRILVGLGG ALSAKGDYRG AERSIDAGLR
     LDEAAFGPNH PDVAVDLEAR GLNLLFAGDL GPSRRYFERA VAIRLRTQGD RHPRVPEDFG
     NLGTVAYLQG NVELAEADYR RALDSYRLML GPEHPEVATT ENNLARIMIE RQGFREALPL
     LEHAVAVNMR EKGPDHDDII FPLSNLAIAE RGVGAFGKAE QLLRRAARTA RLRQHRNLGP
     ILTELADLRC RSKDESGGLK LLDEARPITA KDYPGDPWRV AWVDNTRAYC LAHTNPDEAR
     RLNAASFPVL NAKWGPDTLY GAMARSRQKS LP
//