ID A0A0E9NC41_SAICN Unreviewed; 597 AA.
AC A0A0E9NC41;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Vacuolar protein-sorting-associated protein 36 {ECO:0000256|RuleBase:RU367095};
DE AltName: Full=ESCRT-II complex subunit VPS36 {ECO:0000256|RuleBase:RU367095};
GN ORFNames=G7K_1602-t1 {ECO:0000313|EMBL:GAO47394.1};
OS Saitoella complicata (strain BCRC 22490 / CBS 7301 / JCM 7358 / NBRC 10748
OS / NRRL Y-17804).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Taphrinomycotina incertae sedis; Saitoella.
OX NCBI_TaxID=698492 {ECO:0000313|EMBL:GAO47394.1, ECO:0000313|Proteomes:UP000033140};
RN [1] {ECO:0000313|EMBL:GAO47394.1, ECO:0000313|Proteomes:UP000033140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17804 {ECO:0000313|EMBL:GAO47394.1,
RC ECO:0000313|Proteomes:UP000033140};
RX PubMed=21914972; DOI=10.2323/jgam.57.243;
RA Nishida H., Hamamoto M., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic yeast Saitoella complicata.";
RL J. Gen. Appl. Microbiol. 57:243-246(2011).
RN [2] {ECO:0000313|EMBL:GAO47394.1, ECO:0000313|Proteomes:UP000033140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17804 {ECO:0000313|EMBL:GAO47394.1,
RC ECO:0000313|Proteomes:UP000033140};
RX PubMed=24646756; DOI=10.2323/jgam.60.7;
RA Nishida H., Matsumoto T., Kondo S., Hamamoto M., Yoshikawa H.;
RT "The early diverging ascomycetous budding yeast Saitoella complicata has
RT three histone deacetylases belonging to the Clr6, Hos2, and Rpd3
RT lineages.";
RL J. Gen. Appl. Microbiol. 60:7-12(2014).
CC -!- FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex
CC required for transport II), which is required for multivesicular body
CC (MVB) formation and sorting of endosomal cargo proteins into MVBs.
CC {ECO:0000256|RuleBase:RU367095}.
CC -!- SUBUNIT: Component of the endosomal sorting complex required for
CC transport II (ESCRT-II). {ECO:0000256|RuleBase:RU367095}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367095}.
CC Endosome {ECO:0000256|RuleBase:RU367095}.
CC -!- SIMILARITY: Belongs to the VPS36 family.
CC {ECO:0000256|ARBA:ARBA00009697, ECO:0000256|RuleBase:RU367095}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAO47394.1}.
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DR EMBL; BACD03000008; GAO47394.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0E9NC41; -.
DR STRING; 698492.A0A0E9NC41; -.
DR OMA; RVCYVDH; -.
DR Proteomes; UP000033140; Unassembled WGS sequence.
DR GO; GO:0000814; C:ESCRT II complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043130; F:ubiquitin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.260; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR021648; GLUE_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR040608; Snf8/Vps36.
DR InterPro; IPR037855; Vps36.
DR InterPro; IPR031558; Vps36-NZF-N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR13128; VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36; 1.
DR PANTHER; PTHR13128:SF12; VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36; 1.
DR Pfam; PF04157; EAP30; 1.
DR Pfam; PF16988; Vps36-NZF-N; 1.
DR Pfam; PF11605; Vps36_ESCRT-II; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00547; ZnF_RBZ; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51495; GLUE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367095};
KW Endosome {ECO:0000256|RuleBase:RU367095};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein transport {ECO:0000256|RuleBase:RU367095};
KW Reference proteome {ECO:0000313|Proteomes:UP000033140};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367095}.
FT DOMAIN 7..280
FT /note="GLUE N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51495"
SQ SEQUENCE 597 AA; 65037 MW; 5D3B63E98E2C3D5D CRC64;
MHRWSKINLT SARRPELSED ETTLFVQIHV GLYDGKYKSA DHQNGAIYLT SKRVCYVDSA
QSGQNSVGLE LALIDSYDTY AGFMRSSPKI TLHLHDKASA TASNVNSGIV TPDSSNVTAQ
PTTLPLTQWI CPICSFSNPL PSQYTSSASA PPCLTCGIKP APEVLAKAAA QRPAPVSLPN
PAEVFSSSDD DHTFACPVCT FHNHPSLTSC EMCGSPLMSS NLPPALRNTA GAESPGPMSS
GIVRARYVKI SFRQGGERQF LERLRGALRE RRWEAAPPIG DLQITPIPEQ RGFGIGGLQR
ADESVRKTNE VAMGNALEDL DALMKRAKEM VALAEAFAHR LASAPSTTGN TEARAALLES
TQALGLSSPV VTREITGGND VYHAELAKQV AEFLESGILQ KEGGTVTLID LFALYNRARG
VALVSPADLA KACTLFAQLK LPVRLRTFKS GLVVVHDASR KDETVIRRLK EWISSYETGA
TCQETAEQFK WSVGVALEEL ELAEASGTLC RDESIEGVKF WINEFITFTW DVDSVRGAWE
AVNSVLHIGC TYRHHLLFVP GVPQCTLESG ISLFRAKATG QTNYHRILPI RKEDSFR
//
