GenomeNet

Database: UniProt
Entry: A0A0E9NFH2_SAICN
LinkDB: A0A0E9NFH2_SAICN
Original site: A0A0E9NFH2_SAICN 
ID   A0A0E9NFH2_SAICN        Unreviewed;       228 AA.
AC   A0A0E9NFH2;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|ARBA:ARBA00020629, ECO:0000256|RuleBase:RU364141};
DE   AltName: Full=Mediator complex subunit 4 {ECO:0000256|ARBA:ARBA00031257, ECO:0000256|RuleBase:RU364141};
GN   Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN   ORFNames=G7K_2783-t1 {ECO:0000313|EMBL:GAO48612.1};
OS   Saitoella complicata (strain BCRC 22490 / CBS 7301 / JCM 7358 / NBRC 10748
OS   / NRRL Y-17804).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Taphrinomycotina incertae sedis; Saitoella.
OX   NCBI_TaxID=698492 {ECO:0000313|EMBL:GAO48612.1, ECO:0000313|Proteomes:UP000033140};
RN   [1] {ECO:0000313|EMBL:GAO48612.1, ECO:0000313|Proteomes:UP000033140}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-17804 {ECO:0000313|EMBL:GAO48612.1,
RC   ECO:0000313|Proteomes:UP000033140};
RX   PubMed=21914972; DOI=10.2323/jgam.57.243;
RA   Nishida H., Hamamoto M., Sugiyama J.;
RT   "Draft genome sequencing of the enigmatic yeast Saitoella complicata.";
RL   J. Gen. Appl. Microbiol. 57:243-246(2011).
RN   [2] {ECO:0000313|EMBL:GAO48612.1, ECO:0000313|Proteomes:UP000033140}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-17804 {ECO:0000313|EMBL:GAO48612.1,
RC   ECO:0000313|Proteomes:UP000033140};
RX   PubMed=24646756; DOI=10.2323/jgam.60.7;
RA   Nishida H., Matsumoto T., Kondo S., Hamamoto M., Yoshikawa H.;
RT   "The early diverging ascomycetous budding yeast Saitoella complicata has
RT   three histone deacetylases belonging to the Clr6, Hos2, and Rpd3
RT   lineages.";
RL   J. Gen. Appl. Microbiol. 60:7-12(2014).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364141}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364141}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAO48612.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BACD03000016; GAO48612.1; -; Genomic_DNA.
DR   RefSeq; XP_019023111.1; XM_019170250.1.
DR   AlphaFoldDB; A0A0E9NFH2; -.
DR   STRING; 698492.A0A0E9NFH2; -.
DR   GeneID; 30187097; -.
DR   OMA; THSAFEA; -.
DR   Proteomes; UP000033140; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019258; Mediator_Med4.
DR   PANTHER; PTHR13208; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR   PANTHER; PTHR13208:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR   Pfam; PF10018; Med4; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364141};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033140};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364141};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364141}.
FT   REGION          178..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..228
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   228 AA;  24736 MW;  095297590522295B CRC64;
     MNGDQSAIKL PVALAAYEAA VTSLLSSFTV SQFNPETTHS AFEALLEADK ALNEALDEAD
     LHTAQHNRIL GLQHQSRSLS TQISSALRTL STARQTLQHL PTSLAPISTP STSTTTNTKV
     DAQTLLSYAA KIAPFTGAPS AALPWPDETK LRVGVLGMGP EAGSLARQRA IEEFQERERR
     KVEEASQPPA EVKEVVNDVH MEDQHHHEHG EEEEGEDLGL DLFDPDAE
//
DBGET integrated database retrieval system