ID A0A0E9NGI9_SAICN Unreviewed; 973 AA.
AC A0A0E9NGI9;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=G7K_3110-t1 {ECO:0000313|EMBL:GAO48949.1};
OS Saitoella complicata (strain BCRC 22490 / CBS 7301 / JCM 7358 / NBRC 10748
OS / NRRL Y-17804).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Taphrinomycotina incertae sedis; Saitoella.
OX NCBI_TaxID=698492 {ECO:0000313|EMBL:GAO48949.1, ECO:0000313|Proteomes:UP000033140};
RN [1] {ECO:0000313|EMBL:GAO48949.1, ECO:0000313|Proteomes:UP000033140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17804 {ECO:0000313|EMBL:GAO48949.1,
RC ECO:0000313|Proteomes:UP000033140};
RX PubMed=21914972; DOI=10.2323/jgam.57.243;
RA Nishida H., Hamamoto M., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic yeast Saitoella complicata.";
RL J. Gen. Appl. Microbiol. 57:243-246(2011).
RN [2] {ECO:0000313|EMBL:GAO48949.1, ECO:0000313|Proteomes:UP000033140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17804 {ECO:0000313|EMBL:GAO48949.1,
RC ECO:0000313|Proteomes:UP000033140};
RX PubMed=24646756; DOI=10.2323/jgam.60.7;
RA Nishida H., Matsumoto T., Kondo S., Hamamoto M., Yoshikawa H.;
RT "The early diverging ascomycetous budding yeast Saitoella complicata has
RT three histone deacetylases belonging to the Clr6, Hos2, and Rpd3
RT lineages.";
RL J. Gen. Appl. Microbiol. 60:7-12(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAO48949.1}.
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DR EMBL; BACD03000018; GAO48949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0E9NGI9; -.
DR STRING; 698492.A0A0E9NGI9; -.
DR OMA; WQSWSAS; -.
DR Proteomes; UP000033140; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000033140};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 637..973
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..52
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 941
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 973 AA; 110857 MW; 537A0768CEA2A99B CRC64;
MFANFSGDAR RPRNVNLGGK KKEVNREALL KKAQEERRLR EEERRRNAAA SKIQGFLRRR
REVLKMKEEE RREWDRRIEE WAHGQGMVKV SEENWGRLLE AVADLSLFHD VKQDAPRVLW
LLENLLQFDI KSCSGPRLSR ACLILAVFGQ ILLSFLRQPF DGRQPELLRF LSRLSMASCE
KLVPKGYYRE LAAYFVTSPQ YSVDALTAIL APLQITDVDT MGRFVWQFLS VPHLQRHMGE
QGYAQLISNL TPFLVGLLIG AQVVSVAGFV GSSGEEWVLA YLIDIERSAK ASERFSDFSM
AQYIKAISVL LRRLPSSVFK AANTDVAPPF VTDAIEHLSS KQHIQALLAH VSPDTTADLS
GYFISLMKFW PSKEQEVLMQ LSIASTSETG PSLVRTLWED NMRKSGIYSC STSECSARDI
MAAGDDGEWD VLVLFLEVYS RVLLTMVDDE FLSTRNPISL AFIKEMVLIL KNIAFAMYWY
EMPDTILGSA GWTWEEVRGL VTKMLQQLHA RDARRRFLVD GAWLMTERVD MGGFIKAVVE
EDELTSSQEN SDDEDDEEGE RKRTRPRQTF MTPRLNILRH CPFFIPFDVR VQIFREFVYL
DRKKVGLLDN YFHPHRQRAD IRRDRVFEDA FNQIGSMGPR LKGPLSVTFF DSYGMAEAGI
DGGGVTKEFL TAVCRQAFDA NYGLFKETKE NLLYPNPHAF SREKTQLAYY EFLGKIIGKC
LYEGILVDVA FAPFFLLKLV GRSSYLDDLP GLDPELYQGL VFLKQYTGDV ESDLALNFTV
TNNDMGAAKQ VELLPGGADI AVTRANRLQY IYLVSNYRLN TQLAHQSRAF VRGLSEMVDK
KWLAMFDQAE LQTLIGGAPV PINVADLKRN TDYGGYLEKD DTIKYFWEVM EEFADCDRRE
LVKFVTSVAR PPLLGFKELN PKFGIRDAGG DESRLPTAST CVNLLKLPRY RSKQVLKEKM
LYAIRSGAGF DLS
//
