ID A0A0F0CEI2_9CLOT Unreviewed; 397 AA.
AC A0A0F0CEI2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Alanine--tRNA ligase {ECO:0000313|EMBL:KJJ71172.1};
DE EC=6.1.1.7 {ECO:0000313|EMBL:KJJ71172.1};
GN Name=alaS_2 {ECO:0000313|EMBL:KJJ71172.1};
GN ORFNames=CLFS41_25550 {ECO:0000313|EMBL:KJJ71172.1};
OS Clostridium sp. FS41.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1609975 {ECO:0000313|EMBL:KJJ71172.1, ECO:0000313|Proteomes:UP000033604};
RN [1] {ECO:0000313|EMBL:KJJ71172.1, ECO:0000313|Proteomes:UP000033604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FS41 {ECO:0000313|EMBL:KJJ71172.1,
RC ECO:0000313|Proteomes:UP000033604};
RA Poehlein A., Daniel R.;
RT "Genome sequencing of Clostridium sp. FS41.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJJ71172.1}.
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DR EMBL; JYHN01000059; KJJ71172.1; -; Genomic_DNA.
DR RefSeq; WP_045092494.1; NZ_JYHN01000059.1.
DR AlphaFoldDB; A0A0F0CEI2; -.
DR PATRIC; fig|1609975.3.peg.2754; -.
DR Proteomes; UP000033604; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004813; F:alanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 2.40.30.130; -; 1.
DR InterPro; IPR018165; Ala-tRNA-synth_IIc_core.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR012947; tRNA_SAD.
DR PANTHER; PTHR43462; ALANYL-TRNA EDITING PROTEIN; 1.
DR PANTHER; PTHR43462:SF1; ALANYL-TRNA EDITING PROTEIN AARSD1; 1.
DR Pfam; PF07973; tRNA_SAD; 1.
DR SMART; SM00863; tRNA_SAD; 1.
DR SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS50860; AA_TRNA_LIGASE_II_ALA; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KJJ71172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033604}.
FT DOMAIN 1..222
FT /note="Alanyl-transfer RNA synthetases family profile"
FT /evidence="ECO:0000259|PROSITE:PS50860"
SQ SEQUENCE 397 AA; 44580 MW; 629A019C094BD171 CRC64;
MDKSRLYYQT PYVKSFMCTI EQCEKSGKGT WLAVLNQTGF YPEGGGQPFD TGTLNGVAVL
SVHERGDVII HELAAPLEPG TLAEGIIDWQ KRYDNMQQHT GEHILSGLVH RRFGYDNVGF
HMGSEEVTVD FNGPITPEQL DQLENEANQA VYDNVPVKVL YPDKEELDSL DYRSKKELTG
LVRIVEIPDA DMCACCGTHV ENTGEVGIIK IRSMIHYKGG VRIFLLCGRR ALLDYRDRLK
DETRLSNLLS ARLDLVPEAV EKLKNDLQDR EMLMGRLYGQ IFSLRTEQYP EREAPLALFE
EGLNMVQIRQ LSTLLYERKR GSIVMVCSPG NGNEEYQYAL GSGCCDMRAL SKAMNRRLNG
RGGGSALMSQ GTFRADRQSV TKVFLEESAL LMETGAQ
//
