ID   A0A0F0H2K5_9ACTN        Unreviewed;       945 AA.
AC   A0A0F0H2K5;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:KJK49106.1};
GN   ORFNames=UK14_16755 {ECO:0000313|EMBL:KJK49106.1};
OS   Streptomyces sp. NRRL F-4428.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609137 {ECO:0000313|EMBL:KJK49106.1, ECO:0000313|Proteomes:UP000033569};
RN   [1] {ECO:0000313|EMBL:KJK49106.1, ECO:0000313|Proteomes:UP000033569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-4428 {ECO:0000313|EMBL:KJK49106.1,
RC   ECO:0000313|Proteomes:UP000033569};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJK49106.1}.
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DR   EMBL; JYJI01000129; KJK49106.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F0H2K5; -.
DR   PATRIC; fig|1609137.3.peg.3708; -.
DR   OrthoDB; 118142at2; -.
DR   Proteomes; UP000033569; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR033463; sCache_3.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF13185; GAF_2; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF17203; sCache_3_2; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:KJK49106.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033569};
KW   Transferase {ECO:0000313|EMBL:KJK49106.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          351..528
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          549..798
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
FT   REGION          631..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  100194 MW;  E17309BD399C2ADB CRC64;
     MTGRFGRQPT GWGSRMAARL SRGAHSVAGQ VFALQAVIVL LLITAAALAL VFQARYDSQR
     DARNRSLAAA EAFAHAPGLP AALMSPDPTA VLQPLADAAR KASGLDFIAV MDLRGVRYTD
     SRPELIGRRA SDVSRAAAGE SFTQVFKGQP SDAVRAVVPV RNADGEVIGL VGTGIEVEHV
     AHAVEGQLPL LVGAAAGGLL LGTAGAALVS RRLLHQTRGL GAAEMTRMNE HHEAVLHAVR
     EGVLIIGNDQ RLILANDEAR RLLDLPQDAE DHDVAELGLD PRTTELLASG RVVTDHVHLA
     GDRLLAVNVR PTMAYAGRPA GRVVTLRDST ELASVSGRAE VARSRLQLLY DAGVRIGTTL
     DVARTAEELS EVAVPRFADF VTVELLEPVL RGDEPAGGVH TEMRRAAMTG IRTDSPLQPV
     GDLIRFEVPT APMAAALDAG HAVLAADLNA AMGWRAQDSQ GTRVALEYGL HSLISVPLLA
     RGVVLGMANF WRADTPEPFD GEDLSFAEEL GARAAVSVDN ARRFTREHAM AVTLQRSLLP
     RVLPDQSAVD VAFRYLPATA GVGGDWFDVI QLPGARVALV VGDVVGHGVH AAATMGRLRT
     AVHNFSTLDL PPDELLGHLD ELINRIDQDE AGVAGNGNGN GDMVRGADGS RGGAGGEDAG
     PDGTPEGAAA VTGATCLYAV YDPVSGRCRM ASAGHPGPAL IRPGGRVEFP EMPAGIPLGV
     GGMPFEAVEF QLPEDSRLVL FTDGLVEDRD RDFDSGLRLL AETLSRPGRS PDEACSDVLE
     AMLFPVPSDD IALLVADTRR LEADRIAEWE VPGDYSAVSR VRNAGSAQLV EWGLEDIAFT
     AELILSELVT NAIRYGSAPV RVRLLRDRSL ICEVSDGSST SPHLRYAATT DEGGRGLFLV
     AQYAERWGTR YTDRGKVIWA ELPLTGGGEP QAPPLDLDAL EDLAW
//