ID A0A0F0HLE1_9PSEU Unreviewed; 531 AA.
AC A0A0F0HLE1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KJK55207.1};
DE Flags: Fragment;
GN ORFNames=UK12_30100 {ECO:0000313|EMBL:KJK55207.1};
OS Saccharothrix sp. ST-888.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1427391 {ECO:0000313|EMBL:KJK55207.1, ECO:0000313|Proteomes:UP000033409};
RN [1] {ECO:0000313|EMBL:KJK55207.1, ECO:0000313|Proteomes:UP000033409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST-888 {ECO:0000313|EMBL:KJK55207.1,
RC ECO:0000313|Proteomes:UP000033409};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK55207.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYJF01000150; KJK55207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F0HLE1; -.
DR PATRIC; fig|1427391.3.peg.2040; -.
DR Proteomes; UP000033409; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000033409};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 24..102
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 120..531
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 531
FT /evidence="ECO:0000313|EMBL:KJK55207.1"
SQ SEQUENCE 531 AA; 54434 MW; BE0B877DADB1165A CRC64;
MNESSSDSAL ARLLAAAAPS EHRRLVLDLV HTTAVAALKA ARPDAAETLD TTLPFTELGF
DSLASVDLQG RLAAATGLDL PVTLVYDCPT PAALVERLLA GALGTVAAEP APASQADPAD
EPIAIVGIGC RFPGGVDSPD DLWRLLADGG EVLSGFPDDR GWDLAGIFDE DPEAPGKSYV
RSGGFLDTAT EFDADFFGIS PREALAMDPQ QRLVLETAWE ALEHAGIDPA GLRGTEAGMF
FGAEVQEYGP RLHEAPDGLD AYLMTGNAPS VISGRVAYVL GAVGPAVTVD TACSASLVAI
HLACQSLRAG ESSMALAGGV AVMGGPGVFT AFSRQRGLAP DGRCKAFAAA ADGTGFAEGV
GVLVLERLSE ARRNDHRVLA VVRGSAINQD GASNGLTAPS GTSQQRLIRQ ALANAGLTAA
EVDAVDAHGT GTTLGDPIEA GALIATYGQE RPEGAPLLLG SAKSNLGHTQ GAAGVAGVIK
MVLSMRNGYL PKTLHVDAPS PHVNWSAGAV ELLTEGRPWP ETGHPRRAGV S
//
