ID A0A0F0HV61_9PSEU Unreviewed; 455 AA.
AC A0A0F0HV61;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=L-fuconate dehydratase {ECO:0000256|ARBA:ARBA00013142};
DE EC=4.2.1.68 {ECO:0000256|ARBA:ARBA00013142};
GN ORFNames=UK12_15680 {ECO:0000313|EMBL:KJK57588.1};
OS Saccharothrix sp. ST-888.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1427391 {ECO:0000313|EMBL:KJK57588.1, ECO:0000313|Proteomes:UP000033409};
RN [1] {ECO:0000313|EMBL:KJK57588.1, ECO:0000313|Proteomes:UP000033409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST-888 {ECO:0000313|EMBL:KJK57588.1,
RC ECO:0000313|Proteomes:UP000033409};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O;
CC Xref=Rhea:RHEA:22772, ChEBI:CHEBI:15377, ChEBI:CHEBI:21291,
CC ChEBI:CHEBI:37448; EC=4.2.1.68;
CC Evidence={ECO:0000256|ARBA:ARBA00001737};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK57588.1}.
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DR EMBL; JYJF01000042; KJK57588.1; -; Genomic_DNA.
DR RefSeq; WP_045303587.1; NZ_JYJF01000042.1.
DR AlphaFoldDB; A0A0F0HV61; -.
DR PATRIC; fig|1427391.3.peg.4732; -.
DR Proteomes; UP000033409; Unassembled WGS sequence.
DR GO; GO:0050023; F:L-fuconate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR CDD; cd03324; rTSbeta_L-fuconate_dehydratase; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR034610; L-fuconate_dehydratase.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR InterPro; IPR046945; RHMD-like.
DR PANTHER; PTHR13794; ENOLASE SUPERFAMILY, MANDELATE RACEMASE; 1.
DR PANTHER; PTHR13794:SF58; MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDF00111; L-fuconate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000033409}.
FT DOMAIN 207..303
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 455 AA; 49392 MW; 1174B320B1FA5CE3 CRC64;
MKGTTLPATT ARITAVDTYD IRFPTSRELD GSDAMNPDPD YSAAYVVLRT SAGGHEGHGF
TFTIGRGNDV QVAAIDALRE HIVGRPVAEL CADPGSLYRD LIGDSQLRWL GPEKGVMHMA
IGAVVNAVWD LAAKREGKPL WQLLADADPD WLVSQVDFRY IADALTPDEA LELLAKGKQG
AGERAAELLR RGYPAYTTSP GWLGYSDEKL TRLAEQAVAD GFTQIKLKVG ADLEDDIRRC
RAARAAVGPD IRMAIDANQR WNVAEAIEWT NALAEFDPYW IEEPTSPDDV LGHAAVRQGV
HPIKVATGEH VQNRIVFKQL LQAGAIDVLQ LDSARVAGVN ENLAILLLAA KFGVPVCPHA
GGVGLCELVQ HLSMFDYVAL SGTIEDRVVE YVDHLHQHFL DPVVINSGRY RAPTVPGFSA
TMHQATIDTY TYPDGAFWAA DTAADLCGAD TEERA
//
