ID   A0A0F0I6P2_ASPPU        Unreviewed;       324 AA.
AC   A0A0F0I6P2;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Autophagy-related protein 27 {ECO:0000256|ARBA:ARBA00013776};
GN   ORFNames=P875_00034283 {ECO:0000313|EMBL:KJK62846.1};
OS   Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1403190 {ECO:0000313|EMBL:KJK62846.1, ECO:0000313|Proteomes:UP000033540};
RN   [1] {ECO:0000313|EMBL:KJK62846.1, ECO:0000313|Proteomes:UP000033540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1
RC   {ECO:0000313|Proteomes:UP000033540};
RA   Yu J., Fedorova N., Yin Y., Losada L., Zafar N., Taujale R., Ehrlich K.C.,
RA   Bhatnagar D., Cleveland T.E., Bennett J.W., Nierman W.C.;
RT   "Draft genome sequence of Aspergillus parasiticus SU-1.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004358}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Preautophagosomal structure membrane
CC       {ECO:0000256|ARBA:ARBA00004472}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004472}.
CC   -!- SIMILARITY: Belongs to the ATG27 family.
CC       {ECO:0000256|ARBA:ARBA00005363}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJK62846.1}.
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DR   EMBL; JZEE01000593; KJK62846.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F0I6P2; -.
DR   STRING; 1403190.A0A0F0I6P2; -.
DR   Proteomes; UP000033540; Unassembled WGS sequence.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR   InterPro; IPR018939; Autophagy-rel_prot_27.
DR   InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR   InterPro; IPR044865; MRH_dom.
DR   PANTHER; PTHR15071:SF38; AUTOPHAGY-RELATED PROTEIN 27; 1.
DR   PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR   Pfam; PF09451; ATG27; 1.
DR   SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR   PROSITE; PS51914; MRH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033540};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..324
FT                   /note="Autophagy-related protein 27"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002443195"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          26..238
FT                   /note="MRH"
FT                   /evidence="ECO:0000259|PROSITE:PS51914"
FT   REGION          171..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  36056 MW;  C217C674CDDB5F79 CRC64;
     MRIPAGLSSI ILSSALLPSL SAASGFDCAH INVDGYKYDL SELGGVHSLY NVEKTEEHVV
     NTTYVLNICN ILKGASIKGH LKCGTSKNIC GFQYKYPVDG SEETSRAFPI VGLEHLGHGS
     KDPEITRLKK LDPDEEGLLV KLSGGNYVDD EGKQKDAGAV IEFQCDPERS GLEGLKTADE
     SNGEKKEAER RRAEGGDDKE QPPDEEKDRS LQFKSFGKAD DDSYVLKLNW RTKYACDHYP
     KEEKGDSSSH WGFFTWLIII LFLCIAAYLI FGSWLNYNRY GARGWDLLPH GDTIRDIPYI
     FQDWLRRVVN TLQGSGSRGG YSAV
//