ID A0A0F0IMI9_ASPPU Unreviewed; 1992 AA.
AC A0A0F0IMI9;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=P875_00117520 {ECO:0000313|EMBL:KJK67098.1};
OS Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1403190 {ECO:0000313|EMBL:KJK67098.1, ECO:0000313|Proteomes:UP000033540};
RN [1] {ECO:0000313|EMBL:KJK67098.1, ECO:0000313|Proteomes:UP000033540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1
RC {ECO:0000313|Proteomes:UP000033540};
RA Yu J., Fedorova N., Yin Y., Losada L., Zafar N., Taujale R., Ehrlich K.C.,
RA Bhatnagar D., Cleveland T.E., Bennett J.W., Nierman W.C.;
RT "Draft genome sequence of Aspergillus parasiticus SU-1.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK67098.1}.
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DR EMBL; JZEE01000201; KJK67098.1; -; Genomic_DNA.
DR STRING; 1403190.A0A0F0IMI9; -.
DR Proteomes; UP000033540; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000033540};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1992
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002443559"
FT TRANSMEM 1860..1881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1909..1928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 554..1179
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 1212..1849
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 257..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1992 AA; 222947 MW; DD849971F2543767 CRC64;
MAKSVGPSSR MICGWIPLAL ALLESKCQTI IYGVDWALES REAASHGCLA FFSNVERLRL
AHGDRWDGFH YQRRLAKVPR RLPFCTLQGR SYPTSAIKPL NKNRKCHPHK SSFPNTTKKL
RKVDSLHSVH LAAQVDSRCF HSLPPKIQQK LFSKEEQDWF YRAQFEARFF DAAGEAPYPL
EKARHCSRHQ PPEIRFSDGN SIATSRSSTL YFDLSDSDLS SDTDMDNSLC DNFRWFDDNG
DLDLRLDEYH AHVAKVLPNS PPRRRPSLRT APSFNPDVSI RQPTSAVSRQ KAQSVHRSST
FPTAPMNTMT RNSSTRPSSS QSQTHMPRSS TSSIDPSAQY YQDPEARLKL RVYLASPQNF
DEAVEFGFPA QNNERTMPAE RKTKPPIFTG TFLDEEGTSV SDERCDKRMN VARLSYVHNS
RSSDSGRPYP RHQSWLLPPR PGNQQHTGSN REMTLKMTLT RPDLRTTVPP PRVDPLKLPL
EDSGSHLWGS CEDEQGLMRK MWPVMIYRWL LLVSCLLLAL LAQRGAAKSS SPKIAPPTKI
DHKPSSLFYF EDTDTVLMNT VNGDLLRSVD AGETWSAVEG DDGGMKHHVL LIRQHPYDNK
KAYALGPNGR HWVTTDQAKT WASFNIAEFP AIRHYPLVFH GGDSSKVIFQ GEECAGRYCI
VRSYYTTDDF ATVKLLREST GGCAWAVGHP QFAEDLNLAE EIKDRSFCVV PGLKVPLPHA
NRLVYSDDYF RGNAEGTETK LQEGRPVSGV ISTAAVKKFI VAAAKSKGTE ELALYVTVDA
KNWHRAEFDG HRIEEDAYTM LESTNYSLQV DVLTSPRSGM GVLFTSNSNG TYFTRNIEHT
NRNSEGMVDF EKIAGIQGIV LVNTVQNPEE VESGSAKKKI TSRISFDDGR TFQPLKSDGE
NLHLHSVTAL RNIGRVFSSP APGLVMGIGN AGNHLQEYAE CNLYISDDAG VTWRRALKHP
HKYEFGDQGA VVIAVRDDGR VDKINYSLDH GKEWASVELQ HKIYPTMVTT TPDSTSLKFI
VVGSLKEGQD GEHVIYSIDF DGLHERKCEE GDFEKWPARL DEHGKPDCLM GHKQFYMRRR
ANANCFVDEE FKDPEPIFEA CKCTTEDFEC EYRRTEDGKG CALPSPLTPP EGECKNPDDK
FMGPSGWRLI PGDACIRDGG ENLDKEIERS CKDASSPSTD GKIGVTLQLF EARDYVQYYY
LERQSSSSGS DETIIMLSSE HEVYVTHDHG KTWERPLKGE EITRVYLHPY SSDVAFLLTD
GKEGFWTEDR GHTFKPFQAP APPTQDRFLQ VMAFHPVHKD RLIWTGAVDC HSGDCHSDAF
IKKERGKNWE PLLSYVQKCE FESRETRPNS TNLVYCEQFE KQSKNGRLQL LSSDDFFNDN
EVQFVDVINY ATMSEFIIVA SRQPENPDSL VASTSVDGRT FARAQFPPNV QVPVQTAYTV
LESSTHAVFL HVTASSTEGG EYGPIIKSNS NGTSYVLSIS AVNRNSLGYV DFEKAQGLEG
VAVVNVVSNA AEVSKKVPKK LKTMITHNDG AQWMLLPPPA KDADGKSFGC SVVAGKGTDD
CSLHLHGYTE RKDERDTFAS GSAIGLMMAV GNVGDHLAGG DEADTFITND GGISWKSVKK
GKYMWEYGDS GSVIVIVPES KPTKTIHYSL DEGDTWEEFR FSDVEVRIND ISTVPSDTSK
NFLLWARVSN SEVQDKFATF NIDFSGVRPR PCLLDENQGN SDDYYIWEPK HPFQENNCLF
GHSEQYHRKK PSAQCWNDWR ESHVHSIGTN CTCTRADYEC DYNYEPQSDG SCALVTGLPK
PNAMEICKKD PDTIEYWEPT GYRRIPQTTC QGGLNLDHFV SKPCPNKEEE YKQKHGISGV
GLFFAIVTPL AAAGAAGYYA YSKWDGKFGQ IRLGESAGTS QNFLSRDSWL VTVPIAIVAG
TVAVARALPL LVTSLWRGAS GFIRLGRGRG YSRPYASRGS FAARRGDYTS IVDDEDELLG
VEDADLDEDD EA
//
