ID A0A0F0L1K5_9MICO Unreviewed; 380 AA.
AC A0A0F0L1K5;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=3-methyl-2-oxobutanoate dehydrogenase subunit alpha {ECO:0000313|EMBL:KJL27013.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:KJL27013.1};
GN Name=bkdA_1 {ECO:0000313|EMBL:KJL27013.1};
GN ORFNames=RL72_00752 {ECO:0000313|EMBL:KJL27013.1};
OS Microbacterium azadirachtae.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=582680 {ECO:0000313|EMBL:KJL27013.1, ECO:0000313|Proteomes:UP000033448};
RN [1] {ECO:0000313|EMBL:KJL27013.1, ECO:0000313|Proteomes:UP000033448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23848 {ECO:0000313|EMBL:KJL27013.1,
RC ECO:0000313|Proteomes:UP000033448};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL27013.1}.
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DR EMBL; JYIT01000059; KJL27013.1; -; Genomic_DNA.
DR RefSeq; WP_045249485.1; NZ_JYIT01000059.1.
DR AlphaFoldDB; A0A0F0L1K5; -.
DR PATRIC; fig|582680.7.peg.779; -.
DR Proteomes; UP000033448; Unassembled WGS sequence.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KJL27013.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033448}.
FT DOMAIN 61..324
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 41370 MW; F7BBE5D1D46FC783 CRC64;
MQQTTPAMSP PRDEDPRALL PRDEPVRLID ETGAAHGDAD YPMPADELLG RAYRGLVEGR
RINDQANALV RQGRLAVYPS SHGQEACQIA ASMVLGEHDW LFPTYRDSVA VIARGVSPAD
AMVLLKGDWH SGYDPQEHRV APQTTPLATQ LLHAVGFAQA AKHRGEDTVV LALCGDGSTS
EGDFHEALNF AAVFHVPVVF FVQNNEFAIS VPLSRQTAAP SLAHKAIGYG VPGQRVDGND
VAALLAVLGE AVDRARAGGG PSLIEAHTYR MQAHTNADDD TRYRERAEVQ AWVAKDPLTR
LRAHLTARGL LDDAREQELA DGAETIAAAL RDALNTDADL DPEDLFRFVH SARTPQLQEQ
WHRLRDELER SAASTEGGDR
//
