ID A0A0F0L1P8_9MICO Unreviewed; 375 AA.
AC A0A0F0L1P8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=3-methyl-2-oxobutanoate dehydrogenase subunit alpha {ECO:0000313|EMBL:KJL27053.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:KJL27053.1};
GN Name=bkdA_1 {ECO:0000313|EMBL:KJL27053.1};
GN ORFNames=RN50_00118 {ECO:0000313|EMBL:KJL27053.1};
OS Microbacterium foliorum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=104336 {ECO:0000313|EMBL:KJL27053.1, ECO:0000313|Proteomes:UP000033572};
RN [1] {ECO:0000313|EMBL:KJL27053.1, ECO:0000313|Proteomes:UP000033572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12966 {ECO:0000313|EMBL:KJL27053.1,
RC ECO:0000313|Proteomes:UP000033572};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL27053.1}.
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DR EMBL; JYIU01000016; KJL27053.1; -; Genomic_DNA.
DR RefSeq; WP_045252576.1; NZ_JYIU01000016.1.
DR AlphaFoldDB; A0A0F0L1P8; -.
DR KEGG; mfol:DXT68_05010; -.
DR PATRIC; fig|104336.4.peg.123; -.
DR Proteomes; UP000033572; Unassembled WGS sequence.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KJL27053.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033572}.
FT DOMAIN 49..320
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 375 AA; 40517 MW; E97C3612F7F47854 CRC64;
MEHAEMLPRD TAVQLIDADG SVVADETYAM PSIETLLAAY RGLVDGRRIN DQAGALVRQG
RLAVYPSSHG QEACQIGAAL AIAAEDWLFP TYRDSVAVIA RGVAPAEAMV LLKGDWHSGY
DVRAHRVAPQ ATPLATQLLH AVGFAYAAKQ RGEDTVVIAL CGDGATSEGD FHEAMNFAAV
FHVPVVFFVQ NNEFAISVPL SRQTAAPSLA HKAIGYGMPG QRVDGNDVAA VLSVLGEAVD
RARSGGGPTL VEAHTYRMQA HTNADDDTRY REREEVRAWG ARDPLTRLRT HLTGVGALTA
ELEAEYAAGA ERIAAAMREA LNTDTDIDPE DLFRFVTETR SPQREEQWQM LRGEIERTRA
ADAEETAHAT TGGSR
//
