ID A0A0F0LYP4_9MICO Unreviewed; 355 AA.
AC A0A0F0LYP4;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN Name=echA8_3 {ECO:0000313|EMBL:KJL36516.1};
GN ORFNames=DCP95_05700 {ECO:0000313|EMBL:HAN24053.1}, RR49_01526
GN {ECO:0000313|EMBL:KJL36516.1};
OS Microbacterium ginsengisoli.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=400772 {ECO:0000313|EMBL:KJL36516.1, ECO:0000313|Proteomes:UP000033451};
RN [1] {ECO:0000313|EMBL:KJL36516.1, ECO:0000313|Proteomes:UP000033451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18659 {ECO:0000313|EMBL:KJL36516.1,
RC ECO:0000313|Proteomes:UP000033451};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HAN24053.1, ECO:0000313|Proteomes:UP000257479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UBA9152 {ECO:0000313|EMBL:HAN24053.1};
RX PubMed=30148503; DOI=.1038/nbt.4229;
RA Parks D.H., Chuvochina M., Waite D.W., Rinke C., Skarshewski A.,
RA Chaumeil P.A., Hugenholtz P.;
RT "A standardized bacterial taxonomy based on genome phylogeny substantially
RT revises the tree of life.";
RL Nat. Biotechnol. 36:996-1004(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL36516.1}.
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DR EMBL; DMNG01000100; HAN24053.1; -; Genomic_DNA.
DR EMBL; JYIY01000073; KJL36516.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F0LYP4; -.
DR STRING; 400772.RR49_01526; -.
DR PATRIC; fig|400772.4.peg.1547; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000033451; Unassembled WGS sequence.
DR Proteomes; UP000257479; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:HAN24053.1};
KW Lyase {ECO:0000313|EMBL:KJL36516.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033451}.
FT DOMAIN 20..345
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 355 AA; 37774 MW; 93A1722DDABE9D60 CRC64;
MTDVHPTDAG VVVRTEHSLG RLTLDRPAAI NALDVPMIRA LRAALDAWRG DADIDTVLLD
GAGDRGLCAG GDVRALYASI VAGRADEVGV FFREEYALNA AIDEYPAPIV AFADGITMGG
GIGLAGHAAV RIVTERSRLA MPETRIGFTP DVGGSYLLSR APGRLGEYLA LTGDTMSASD
AIHAGFADHF VPSAHLDAIR DALVTRADPS GPAELVLLFD ETPEASELAA KQPWIDATFD
ADTVPGIIAK LRAVGEPEAS ALADRLTHAA PTALAVTLEA VRRARELPTL RAVLEQEYRL
VLWFAHTQPD MVEGIRAQLV DKDRDPHWNP ATHDGVTPDT IAAAFSYEPA VPLWS
//