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Database: UniProt
Entry: A0A0F0XVC6_9ENTR
LinkDB: A0A0F0XVC6_9ENTR
Original site: A0A0F0XVC6_9ENTR 
ID   A0A0F0XVC6_9ENTR        Unreviewed;       509 AA.
AC   A0A0F0XVC6; A0A0H0CSV8; A0A181D0R6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   10-OCT-2018, entry version 25.
DE   RecName: Full=NAD(P) transhydrogenase subunit alpha {ECO:0000256|PIRNR:PIRNR000203};
DE            EC=1.6.1.2 {ECO:0000256|PIRNR:PIRNR000203};
GN   Name=pntA {ECO:0000313|EMBL:KJM88212.1};
GN   ORFNames=DP199_09995 {ECO:0000313|EMBL:RAY73436.1}, SAMEA3181516_02074
GN   {ECO:0000313|EMBL:SAZ28359.1}, SS33_18290
GN   {ECO:0000313|EMBL:KJM88212.1};
OS   Enterobacter kobei.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=208224 {ECO:0000313|EMBL:KJM88212.1, ECO:0000313|Proteomes:UP000033742};
RN   [1] {ECO:0000313|EMBL:KJM88212.1, ECO:0000313|Proteomes:UP000033742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35730 {ECO:0000313|EMBL:KJM88212.1,
RC   ECO:0000313|Proteomes:UP000033742};
RA   McCorrison J., Sanka R., Adams M., Brinkac L., Nierman W., Sutton G.,
RA   Nelson K., Kiedrowski L., Guerrero D., Bonomo R.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SAZ28359.1, ECO:0000313|Proteomes:UP000078120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3380STDY6027363 {ECO:0000313|EMBL:SAZ28359.1,
RC   ECO:0000313|Proteomes:UP000078120};
RG   Pathogen Informatics;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RAY73436.1, ECO:0000313|Proteomes:UP000250452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=131G4 {ECO:0000313|EMBL:RAY73436.1,
RC   ECO:0000313|Proteomes:UP000250452};
RA   Jousset A.B., Oueslati S., Bernabeu S., Takissian J., Creton E.,
RA   Vogel A., Cotellon G., Bonnin R.A., Dortet L., Naas T.;
RT   "ACT-28, a chromosomally-encoded AmpC with carbapenemase activity from
RT   Enterobacter kobei.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CATALYTIC ACTIVITY: NADPH + NAD(+) = NADP(+) + NADH.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
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DR   EMBL; JZYS01000029; KJM88212.1; -; Genomic_DNA.
DR   EMBL; QMCU01000031; RAY73436.1; -; Genomic_DNA.
DR   EMBL; FKLS01000001; SAZ28359.1; -; Genomic_DNA.
DR   RefSeq; WP_023330268.1; NZ_QGLV01000057.1.
DR   EnsemblBacteria; KJM88212; KJM88212; SS33_18290.
DR   EnsemblBacteria; OEG96636; OEG96636; AN674_0205395.
DR   EnsemblBacteria; SAZ28359; SAZ28359; SAMEA3181516_02074.
DR   KEGG; ekb:BFV64_10255; -.
DR   PATRIC; fig|1619246.3.peg.4042; -.
DR   KO; K00324; -.
DR   Proteomes; UP000033742; Unassembled WGS sequence.
DR   Proteomes; UP000078120; Unassembled WGS sequence.
DR   Proteomes; UP000250452; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR008142; AlaDH/PNT_CS1.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR026255; NADP_transhyd_a.
DR   InterPro; IPR024605; NADP_transhyd_a_C.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   Pfam; PF12769; PNTB_4TM; 1.
DR   PIRSF; PIRSF000203; NADP_transhydrogenase_alpha; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00561; pntA; 1.
DR   PROSITE; PS00836; ALADH_PNT_1; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000033742,
KW   ECO:0000313|Proteomes:UP000078120, ECO:0000313|Proteomes:UP000250452};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000203};
KW   NADP {ECO:0000256|PIRNR:PIRNR000203};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000203};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000203,
KW   ECO:0000313|EMBL:KJM88212.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    399    417       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    423    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    477    498       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    137       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      146    311       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
SQ   SEQUENCE   509 AA;  54047 MW;  EB180DB4E9461911 CRC64;
     MRIGVPKERL ANETRVAATP KTVEQLLKLG FTVAVESGAG KLASFDDEAF IQAGAEVVDG
     AEVWQSPVIL KVNAPEESEI ALLNPGTTLV SFIWPAQNPA LMEKLAARGV TVMAMDSVPR
     ISRAQSLDAL SSMANIAGYR AIVEAAHEFG RFFTGQITAA GKVPPAKVMV IGAGVAGLAA
     IGAANSLGAI VRAFDTRPEV KEQVQSMGAE FLELDFKEEA GSGDGYAKVM SEAFIKAEME
     LFAAQAKDVD IIVTTALIPG KPAPKLITRE MVDSMKPGSV IVDLAAQNGG NCEYTVANQV
     TTTANGVKVI GYTDLPGRLP TQSSQLYGTN LVNLLKLLCK EKDGNVTVDF DDVVVRGVTV
     VRDGEITWPA PPIQVSAQPQ AAPKAAPEPK EPAKPASPWR KYAIMALVII LFGWLADVAP
     KEFLGHFTVF ALSCVVGYYV VWNVSHALHT PLMSVTNAIS GIIVVGALLQ IGHGGWISFL
     SFIAVLIASI NIFGGFTVTQ RMLKMFRKG
//
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