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Database: UniProt
Entry: A0A0F2C8P6_9MICO
LinkDB: A0A0F2C8P6_9MICO
Original site: A0A0F2C8P6_9MICO 
ID   A0A0F2C8P6_9MICO        Unreviewed;       437 AA.
AC   A0A0F2C8P6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   10-APR-2019, entry version 15.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   Name=tuaD_1 {ECO:0000313|EMBL:KJQ55078.1};
GN   ORFNames=RS85_01137 {ECO:0000313|EMBL:KJQ55078.1};
OS   Microbacterium sp. SA39.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Microbacterium.
OX   NCBI_TaxID=1263625 {ECO:0000313|EMBL:KJQ55078.1, ECO:0000313|Proteomes:UP000033425};
RN   [1] {ECO:0000313|EMBL:KJQ55078.1, ECO:0000313|Proteomes:UP000033425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SA39 {ECO:0000313|EMBL:KJQ55078.1,
RC   ECO:0000313|Proteomes:UP000033425};
RA   Corretto E., Antonielli L., Sessitsch A., Kidd P., Weyens N.,
RA   Brader G.;
RT   "Draft genome sequences of ten Microbacterium spp. with emphasis on
RT   heavy metal contaminated environments.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJQ55078.1}.
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DR   EMBL; JXRU01000029; KJQ55078.1; -; Genomic_DNA.
DR   RefSeq; WP_046012454.1; NZ_JXRU01000029.1.
DR   EnsemblBacteria; KJQ55078; KJQ55078; RS85_01137.
DR   PATRIC; fig|1263625.4.peg.1152; -.
DR   Proteomes; UP000033425; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000033425};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124,
KW   ECO:0000313|EMBL:KJQ55078.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033425}.
FT   DOMAIN      320    421       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    264    264       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      85     85       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     152    152       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     267    267       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     334    334       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   437 AA;  46413 MW;  DCE312C8A1FBD1A9 CRC64;
     MKISVIGCGY LGAVHAVAMA ELGHDVVGVD VDADRIALLA DGKAPFFEPE LDQLLERGLA
     SGRLQFTTSP TSAADADVHF LAVGTPQKPG AHAADLTYVD AAFATILGVA KSGSLIVGKS
     TVPVGTAQRL AAQLPAHGET VSLAWNPEFL REGFAIKDTL EPDRLVYGVV AGDQGREDAE
     RLDAVYHAAI STGTPRIVTD YATSELVKVS ANAFLATKIS FINAISEIAD VAGADITALA
     DAIGQDARIG RRFLNAGVGF GGGCLPKDIR AFAARAEELG KGSSLAFLNE VDAINLRQRQ
     RVVDLAVEAL GGSVNERRIV ILGVSFKPNS DDVRDSPALD VAVQLKGLGA DVVATDPEGI
     ENARRRHPQL SYVPSLRDAL RDAELVVLVT EWQEYRDIDP RDASSLVARP HIIDGRNALD
     PVRWRASGWT YRGMGRP
//
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