ID A0A0F2E186_STROR Unreviewed; 321 AA.
AC A0A0F2E186;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
GN ORFNames=TZ95_00890 {ECO:0000313|EMBL:KJQ77043.1};
OS Streptococcus oralis subsp. tigurinus.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1077464 {ECO:0000313|EMBL:KJQ77043.1, ECO:0000313|Proteomes:UP000033377};
RN [1] {ECO:0000313|EMBL:KJQ77043.1, ECO:0000313|Proteomes:UP000033377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC5873 {ECO:0000313|EMBL:KJQ77043.1,
RC ECO:0000313|Proteomes:UP000033377};
RA Haase E.M.;
RT "Evolution of amylase-binding proteins of oral streptococcal species.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJQ77043.1}.
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DR EMBL; JYGU01000006; KJQ77043.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F2E186; -.
DR PATRIC; fig|28037.217.peg.864; -.
DR Proteomes; UP000033377; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd13131; MATE_NorM_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR029303; Polysacc_synt_C.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 1.
DR Pfam; PF14667; Polysacc_synt_C; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..98
FT /note="Polysaccharide biosynthesis protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14667"
SQ SEQUENCE 321 AA; 35443 MW; F2D9828CD4561B88 CRC64;
MAAVSVSYLW YLSIGIIPLL LFSVIRSLLD SLGLTKLSMY LMLLLLPLNC GFNYLLIYGG
FGFPELGGAG AGLGTSLAYW CLLGISVIIL LKQEKLQEFH LEKPLPLNLV KIKEGIRLGL
PIGGTVFAEV IIFSVVGLIM AKFLSMIIAS HQSAMNFSTL MYAFPVSISS AMAIVVSYEV
GTKRFDDAKT YIKLGRWIAL IFAGFTLSFL YILRDVVASL YGNNPDFIEL TSTFLTYSLF
FQLADTVAAP LQGILRGYKD TVVPFYLGVI AYWAVSIPLG LFLDHVTTLG AYSYWIGLIA
SLVVSAILYQ WRLQTIMKKI N
//
