ID   A0A0F2L422_9CREN        Unreviewed;       227 AA.
AC   A0A0F2L422;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KJR72203.1};
DE   Flags: Fragment;
GN   ORFNames=TU36_03510 {ECO:0000313|EMBL:KJR72203.1};
OS   Vulcanisaeta sp. AZ3.
OC   Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Vulcanisaeta.
OX   NCBI_TaxID=1609231 {ECO:0000313|EMBL:KJR72203.1, ECO:0000313|Proteomes:UP000054362};
RN   [1] {ECO:0000313|EMBL:KJR72203.1, ECO:0000313|Proteomes:UP000054362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Servin-Garciduenas L.E., Martinez-Romero E.;
RT   "Metagenome Sequencing of an Archaeal-Dominated Microbial Community from a
RT   Hot Spring at the Los Azufres Geothermal Field, Mexico.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|ARBA:ARBA00008785}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJR72203.1}.
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DR   EMBL; JZWU01000085; KJR72203.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F2L422; -.
DR   Proteomes; UP000054362; Unassembled WGS sequence.
DR   GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 2.
DR   Pfam; PF03949; Malic_M; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
FT   DOMAIN          20..153
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   NON_TER         227
FT                   /evidence="ECO:0000313|EMBL:KJR72203.1"
SQ   SEQUENCE   227 AA;  24537 MW;  D0A15B7889149611 CRC64;
     MGEESSKWFR IAVEASRRYS GKIMVLPKVP VRSLQDFSIW YTPGVAEVSR EISKNLDLSF
     EYTWRWNAIA VLTDGTRVLG LGNVGPEAAI PVMEGKSLLY KYLGGVDAVP LPVRTGTADE
     LISVAKAIEP AFGGINLEDI ESPKCFYVLD KLREELKIAV WHDDQQGTAG AILAGLINAF
     KIVGKKMEDS TIVFVGAGAS NVAAARILMK AGVKPGNIIL VDSKGIL
//