ID   A0A0F2LXH5_SPOSC        Unreviewed;      1186 AA.
AC   A0A0F2LXH5;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Ribonuclease II/R domain-containing protein {ECO:0000259|SMART:SM00955};
GN   ORFNames=SPSK_04857 {ECO:0000313|EMBL:KJR80596.1};
OS   Sporothrix schenckii 1099-18.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR80596.1, ECO:0000313|Proteomes:UP000033710};
RN   [1] {ECO:0000313|EMBL:KJR80596.1, ECO:0000313|Proteomes:UP000033710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1099-18 {ECO:0000313|EMBL:KJR80596.1,
RC   ECO:0000313|Proteomes:UP000033710};
RX   PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA   Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA   Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA   Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA   Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA   Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA   Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA   Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA   Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA   Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT   "Comparative genomics of the major fungal agents of human and animal
RT   Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL   BMC Genomics 15:943-943(2014).
RN   [2] {ECO:0000313|EMBL:KJR80596.1, ECO:0000313|Proteomes:UP000033710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1099-18 {ECO:0000313|EMBL:KJR80596.1,
RC   ECO:0000313|Proteomes:UP000033710};
RX   PubMed=25480940;
RA   Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA   Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA   Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA   de Camargo Z.P., Felipe M.S.;
RT   "Asexual propagation of a virulent clone complex in a human and feline
RT   outbreak of sporotrichosis.";
RL   Eukaryot. Cell 14:158-169(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJR80596.1}.
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DR   EMBL; AXCR01000012; KJR80596.1; -; Genomic_DNA.
DR   RefSeq; XP_016583272.1; XM_016731619.1.
DR   AlphaFoldDB; A0A0F2LXH5; -.
DR   GeneID; 27666896; -.
DR   KEGG; ssck:SPSK_04857; -.
DR   VEuPathDB; FungiDB:SPSK_04857; -.
DR   OrthoDB; 12396at2759; -.
DR   Proteomes; UP000033710; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   PANTHER; PTHR23355:SF42; EXORIBONUCLEASE II, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF00773; RNB; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
PE   4: Predicted;
FT   DOMAIN          602..1013
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
SQ   SEQUENCE   1186 AA;  129229 MW;  4D362EFC7CD67656 CRC64;
     MVASKKSSDA TRMAWMAQTS DSEVTRGTRG VPSIREQLRD FVALELATAR PIPRDAARLG
     TTENSLTRVE SHTLAEIKTG ETSLDVTDDT DQVLPWGSVG GDPDDAPSLL ARPYGVVAPR
     AGDLIEIRTD SWRVQLLAVC LGNFRGVDHF YTNTGKWFVS SGVRSLFAVT RFATPDDLAP
     LIAALPSEAL QETTTDSSGA GGKDAAALDS KLNMLQDLKL GPSREAGAGL LKKMADFAEQ
     ATGIHMAHAG VLDNAFDVLQ LSEQDSGKSS GKVSGNTSDS APQHRKTYMT LDQLASVLLR
     RQGYKHLGPR GQHNNHRHHF PIRNLRGRGS GAEGMDEFTA PAMYAVYRSI VSNDLAFRPL
     TTTLGNASET DDALSPGAVD TGEKRHSHSR SCLFAIAPRE DIDIIHGVDR IVRSFYEDPD
     RVSSGGQLSD KALAKKTLGS FILKARRSID RSRKTRDWSP YGMLGTAERN PKHNVHSNFE
     QWSPSDVAIL QFMHLWASSQ RFSPSSRLHG TGSAILRALD RYTECQFLVM STGWTFLQEV
     GWVTPWDLPA RYKLGLPDIP PLRTGGLERS LEQLPSPSVD FSATDSASTA SPLSEDIFEG
     KRRDWGDLTA FCIDAPEAAD IDDGVALERI ANCPDEFWIH AHVADPGSRI RPGSALAEQA
     ARMPQTAYLP GHHECMFPDD VVRKQFSLGP GQPCLTFSAR VNRQGDVLTS KITPGRLGRV
     IFIAPSQVSS VVANAEQRAI RDNNIDALAE PSALELPWTT TSFSVGTPSA TTKVDPSSPA
     ARTMTTADKL TPDQKEDLET LSTLATALRA VRLAHGAMPL YWPRPSVDVS LDNTNVVVVD
     AAAQSGPPKA ADMISSTSSK HSIPASLLQT SGDPYIRIWY EGADAVSAAA AASSAAGSRL
     VESIMRLAGE VAANWCHERN IAVPFRGQPD AVRHLDRLRE LTRDEIYPAL VSGKRPEDAS
     LRELRRLLGA DDMTAVPVPH VTMGVARYTK ATSPLRRYSD LLVHWQVEGA LLAEMKDSES
     NATPLKASPP AGPPFTRTEM EQDILPLLRV RERALRSLDN QAGRDQWILQ AMVRAWLGEE
     ARITSRADKD SEATETTTST PFANLHLTVS RIDRRRGLVS GRLDWFEQTA VMDVLSLNAT
     GPDRDNDGMQ RLTLEDIQPG QVYPVALSHV DVHGNMVLVR RLGDAL
//