ID A0A0F2LY77_SPOSC Unreviewed; 806 AA.
AC A0A0F2LY77;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=alpha-L-rhamnosidase {ECO:0000256|ARBA:ARBA00012652};
DE EC=3.2.1.40 {ECO:0000256|ARBA:ARBA00012652};
GN ORFNames=SPSK_03067 {ECO:0000313|EMBL:KJR82427.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR82427.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR82427.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR82427.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR82427.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR82427.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing alpha-L-rhamnose residues
CC in alpha-L-rhamnosides.; EC=3.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001445};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR82427.1}.
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DR EMBL; AXCR01000010; KJR82427.1; -; Genomic_DNA.
DR RefSeq; XP_016585103.1; XM_016729910.1.
DR AlphaFoldDB; A0A0F2LY77; -.
DR GeneID; 27665187; -.
DR KEGG; ssck:SPSK_03067; -.
DR VEuPathDB; FungiDB:SPSK_03067; -.
DR OrthoDB; 67137at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR035396; Bac_rhamnosid6H.
DR PANTHER; PTHR34987:SF5; ALPHA-RHAMNOSIDASE; 1.
DR PANTHER; PTHR34987; C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED; 1.
DR Pfam; PF17389; Bac_rhamnosid6H; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..806
FT /note="alpha-L-rhamnosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002454608"
FT DOMAIN 306..521
FT /note="Alpha-L-rhamnosidase six-hairpin glycosidase"
FT /evidence="ECO:0000259|Pfam:PF17389"
FT REGION 129..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 86475 MW; 8BE13240BE476F5D CRC64;
MVVGIGSHGL SKAYVLVAVL SQVFGVKADT RKCWKDTPCD SRFDETAFPG PWEDSILAAA
TRTITPRSVV ETLTKTVNGD LIPTSRAPYD PTKVPLVLAG NGSQVVFDFG QEVGGLVTLI
YTVSRNDEIH IGGDDDDDDD DDAENRDHST RDAPTSRKAR IGLAFSESSD FIGQWSDASN
GAFQGPDGAI YAEIDEPGET TYTMPDASLR GGFRYLTVFL EADGDGNAGL VAALHNVTLD
IAFQPTWPNL RAYQGYFDCD DPLLNRIWYA GAYTLQTNAV PPTTGRHVPF LKTGWANDGL
LGPGHTILVD GAKRDRAVWP GDMGVAVPSL FVSTGDMESV KNALQTMYDN QNPDGSFPEA
GPPLLQQGSD TYHMWTMIGT YNYVLYTNDT TFLARNWAGY QRAMSFITAK QVQVDSKRGL
LNATGVRDWA RLNVGGNMTE AQVILYQTLT TGTQLGTWLG TNATGNTSTV WAAAAEHLRN
ITLATCYDPQ VGLFRDNALP SSKIYPQDAN ALALAFGMTS SSVTAVSYDV DTFSVNISDN
LVRNWQSAAN PYPVTPELPG HVSPFISSWE VRGHFLARET DRALKLVRSV WGGYLDRLDG
SQSSLVEGHV IDPGSEGLSF GYRWNRGYGG AHNDTAVAAS YTSHSHGWSA GPTSALTEFV
LGLSVTGVAG STWQFAPQMG GRGSGTKGIG RAEGGFITPL GKFQASWVCS CFANGTCDDI
GKSDNSFEAT VNTPQNTSGV IILPIAGIVE KDAMKSGAAV RVVLNNFVIQ NPQIEDVGNR
GKDKASVAVL HVQGGSNTVK ISRVLD
//
