ID A0A0F2LZW4_SPOSC Unreviewed; 1128 AA.
AC A0A0F2LZW4;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=SPSK_03912 {ECO:0000313|EMBL:KJR82998.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR82998.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR82998.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR82998.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR82998.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR82998.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR82998.1}.
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DR EMBL; AXCR01000010; KJR82998.1; -; Genomic_DNA.
DR RefSeq; XP_016585674.1; XM_016730727.1.
DR AlphaFoldDB; A0A0F2LZW4; -.
DR GeneID; 27666004; -.
DR KEGG; ssck:SPSK_03912; -.
DR VEuPathDB; FungiDB:SPSK_03912; -.
DR OrthoDB; 2230730at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 616..696
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 121321 MW; B022C1498C551F83 CRC64;
MATAAPVLSS AASPLSPHSQ LRTEGSTVEN DASSSTPTPP LRVVNDLLAR RVREGPHSPF
FAYPATPRGK DDYVHHTVGD IDRYADAAAS LYLQSGVVPH HPSAQNAEVV ALLAPSSVDY
VVSMFALSRL GFAVLLLSNR LATEAIVNLL QKTQCTKMIV SPHYVTAAIE AAAAASTANG
QGHGPVSVFS LSEYERYTTV SAPTDTAAAA VAADNHALVE AAWPSFATMP ATSLATRIAF
VIHSSGSTGL PKPIFQTHAA CLANYESGIP YRAFITLPLF HNHGLSTLFR ALCAGKAAAL
YNANLPLAGS TLVASMRAVA PESLHCVPYA LKLMAEDPRG IDALRALKLV LYGGSSCPDE
LGDRLVAAGV YLAGHYGATE MGQLMTSFRD PEMDKEWAYM RPVPSAKPFL RMVPLGAGAE
GIDTTYECVV LDGLPSKVLS NSDDPPNSFH TRDLFAKHPT MHDAWKHLGR IDDRVTLFNG
EKVLPIPYEH QIRQHDLVRE CVVFGVGRAV PGIMIVPSDK AASLVSEGNN KLLLDALMPA
IEATNAQTEA FGRISREMVA ILPADTEYPC TDKGTVIRAA FYQRFAAEIE AVYVRFEGAA
GDDAEVTASS KPLLTLSETE LERYLLDLFT KLLGVSADRL QADTDLFDAG VDSLQAITAR
ALILREIDLG GRKPGHNVVF ELPSIRQLAQ HFVALRTGSN GEHDSNDASE IKAMDELIAK
YSDFSANATF DATTTKARHG GPQTVLLTGA TGSLGAHILH QLVQQDAQHV ARVYCLVRAP
SRATAEERVQ ATLAAKGLSP LPRDERVVCL SADLSQGSLG LDDTMLADFR ETLTTVVHAA
WAVNFNLGVR SFESQHIRGT RNLLDVALSN VGGRRPAARL FFCSSISAAA GAPLPATISE
GYITNLHHAQ AMGYARSKVV TEHIVRAAAK QTGMTARVLR LGQIIGDTER GIWSTSEAIP
LIFQSARTTG ALPALDETPS WMPVDAMARA VLELSGLTGR PEEDDADTGD TGDIVDLSTV
YQVQNCKVFR WTDDLLPALR AAGLEFEVVP QREWVARLRA SDPDPRRNPA IKLIDFYTEK
YDNDRPGRAG LVFDTHKTEA ASATAQSGFD VIGSGLVAKM VSWWKTQW
//
