ID A0A0F2M0M9_SPOSC Unreviewed; 2155 AA.
AC A0A0F2M0M9;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=SPSK_02914 {ECO:0000313|EMBL:KJR82629.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR82629.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR82629.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR82629.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR82629.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR82629.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR82629.1}.
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DR EMBL; AXCR01000010; KJR82629.1; -; Genomic_DNA.
DR RefSeq; XP_016585305.1; XM_016729762.1.
DR GeneID; 27665039; -.
DR KEGG; ssck:SPSK_02914; -.
DR VEuPathDB; FungiDB:SPSK_02914; -.
DR OrthoDB; 1386981at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 352..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1202..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1245..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1287..1312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1333..1360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1459..1481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1540..1560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1572..1590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1602..1622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1628..1646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1658..1683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1751..1777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1796..1831
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2056..2080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2094..2126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2063..2080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2155 AA; 241523 MW; 7B7745C7BCE83C8A CRC64;
MARRPGEFDD GYAFVSSDTE LPPADTYSAN PQTPYEPYEQ RPSVQPTVPT STHLPDITTY
WADTGLSTHQ SLPHGASQRG NELASPESPI DPAALQFALP PNIFQTGPIS VDRDFEPPSA
DAFAAISTAY YDDHSHFDPS SDSDRVPLTA SAEPISGSSG VPPDGIQSHN SFQTVASSDG
GQEETRDSRM LGYDLEPGYD TGGRQRSYGN SLTPDNTTRR PRSTSTTGAL QKTASIVRAM
SQRVVDISGG GEALEQQALR DRSRSPSRDA QSTHHLSSPV LVDTSYQPQV FGTPLEKKGE
SEFAVSQPPP LSHYRAPMPN PLRGKSLGIF SADNTFRLWL CDLLMLPWVE SFILVLIVLQ
AVLLAVEAAP DVWSQGNGRP ERWGKTPYDW AKLGLFVVFT LEIIARIIVS GFVFNAAEYS
TIDRKRGMRQ GVRAAVTDQY RSFFQPQRQR SVKRPPVETY GPSSFARSFT LMQGQPLPET
YEEQQRMQLA RRAFLRHSFS RLDFVAVVSF WVSFVLSITG IEYQYHLYVF RMLSCLRIVR
LLGITKGNAI ILRSLKKAAP LLVRVSFLIV FFWLLFAIIG VQSFKSSLSR QCVWLDPSQP
DNLTAAYTNE FGFCGGHLKN DSNPNPTTLP WVMMTEAGNL SSLVNGTRNG KGFVCPRGSI
CLQQESPYNA TVNFDDILHS LELVFVIMSA NTFSDLMYYT TNSDYLVAAL FFAAGIMIMM
LWMTNLLIAV ITSSFQVIRE ESKGSAFTAD ENDFLASRPD SGLRRATMLR RIYQKITWFW
ILAIAFDLFV QAFRSASHEG RIGFINTCEV VVTVLLDIEI VIRFSSDWRR FHHSIQNLFD
LGLAVITSVI LIPPIRNSGQ VYAWLTVFQI LRAYRVVLAI PMTRTLIKLV LGNATGIGNL
MLFVFLITFL VSIFAVQLFR GEITPQDSSG NDIRITFASI FNSFLGMYQI LSSENWTAVL
YTVTGFTKRL DTAWIGAIFL IGWFILSYFI LINMFIAVIQ ENFDVSEDQK RLEQVKAFLQ
RRELGTSASN LSLSAMFSLG RRAKRKDPLD YGPGMMEMLL KEAVVREFLN EALDPLQDST
AGNQSSSQVQ DVLSGTAKAG VLPVIWAKVS RWTSSKDPNP FYSNVRFDVR NENLDPRQMA
RQAVSATSAR RKAQREYLGR HPTYNNSLFI FTPRNPLRRL CQRLVGPGRG SERFDGVEPN
KYAWYTFSAF IYASIVAMVI IACVTTPLYQ KQYFDGGHTF SFKNWFVWTD MAFAIVFTVE
AVVKIIADGF FWTPNAYFRS SWGIIDAVVL ITLWINVATL FANDGAVSRA VGAFKALRAL
RLLNVSDSAR ETFHSLIIVG GWKILSAAFV SISLLIPFAI YGLNLFRGQM VSCNDQSGSV
LRLQDCTGEY LNTPFSNDWQ LLSPRVAENP YYSFDDFGSS ILILFTIVSQ EGWVDVSFQA
QSVTGVGNQP RFGAAQGNAL FFVAFNLLAT IFVLTLFISV FMRNYTEQTG VAFLTGDQRA
WLELRKLLRQ ISPSKSSYDD SKNKLKKWCH KRAIEKHGKW YVGITMVLVL HLILLILEYS
SEPDWWTNTR DYVFLVFTLV YMANISIRIV GLGWSRFRRS SWDVFSMCAV AGAFATSILF
LAEPGQDTFI QLHKFFLVAI VLLLIPRNDA LDQLFKTAAA SVTTIGSLLA TWLVFFLVFA
IAMTQSFSLT RFSSQETNNI NLRTVPNALI LLFRMSCGEG WNQIMEDFAG VEPPLCVEAP
TFFGSDCGST AWARVLFIAW NIISMYIFVN LFVSLIYESF SYVYQRSSGL ADISRDEIRR
FKEAWRSVDP NGTGFISREA FPRLLGELSG VFEMRIYDHE DSVRSILEFA RNDDTTPQAR
HASLASQTAL TGVNLQKLND RINQIDLNRV RERRRRFNIF YEEVMVSADP DKGIFFTTVL
MILAHYNIIS DSKSLRLEEF LRRRARLQRV EEEARRRVVL GFFNTLYWSR KFRRHMEQKR
SARMTGVPQL GIPDILVDDE DDRTSGAGAG HSTGAASLQT AATFLSADHA AGPAQHHRSW
SGASIDISLH DTNYAHPLSA PRTGGLSSPT SSGGLQPQRH HYNSSAFSFE LQEPSAQFEA
DGSRRGSAVS AMSGASGMSG VSGVSPGLVR EMLDDSVWVE SIRRSATQRR SGWGT
//
