ID A0A0F2M9C2_SPOSC Unreviewed; 1507 AA.
AC A0A0F2M9C2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=ATP-dependent helicase STH1/SNF2 {ECO:0000313|EMBL:KJR85679.1};
GN ORFNames=SPSK_08306 {ECO:0000313|EMBL:KJR85679.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR85679.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR85679.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR85679.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR85679.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR85679.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR85679.1}.
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DR EMBL; AXCR01000007; KJR85679.1; -; Genomic_DNA.
DR RefSeq; XP_016588355.1; XM_016734909.1.
DR GeneID; 27670186; -.
DR KEGG; ssck:SPSK_08306; -.
DR VEuPathDB; FungiDB:SPSK_08306; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd04369; Bromodomain; 1.
DR CDD; cd17996; DEXHc_SMARCA2_SMARCA4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR014978; Gln-Leu-Gln_QLQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029295; SnAC.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR10799:SF973; ATP-DEPENDENT HELICASE BRM; 1.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF08880; QLQ; 1.
DR Pfam; PF14619; SnAC; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00951; QLQ; 1.
DR SMART; SM01314; SnAC; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS51666; QLQ; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Helicase {ECO:0000313|EMBL:KJR85679.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 157..192
FT /note="QLQ"
FT /evidence="ECO:0000259|PROSITE:PS51666"
FT DOMAIN 407..480
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 590..755
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 901..1052
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1353..1416
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 69..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1340
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1451..1466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 168591 MW; 690000784E333E09 CRC64;
MASVQASAAA MPLANTAPPN GITPQQVQEV YSRFRQMKEQ GVPQTDPDFI KTQQFLLNIQ
QQQAFKRQMQ HQRDTQQAAQ QAAAAAANGA IMNGGGAPHP GRQAPGFPGT PMGRPMPPNA
AAGGAAPATP GSAGSGAPAG AGAGAGAGTA ASPVTGHFSQ QQLSLLRHQI QAFKHLSRNA
GVPMQTQQVI FGQRARRQIA SVSEKLAGTK TPATPTTAAA RKGAAAAASG GADAAKADAD
GAAPGSQELT APGRKVKSFK TVQSPYESGA VRKTISYFDH GRRINRPVIP GILPTGIDFD
ALRTEREKIV FNRMSARYAE LKSLPSNISH WDTATNSLTP DDTIKRKAYI EMKCLGLYSL
QRALRDKIGR QMMHYDNLAM TTNRSNYRRM KRQNVREARI TEKLEKQQRD AREHREKKRH
SDFLAAVTKH RAELTTTANQ QRNKMQKLGR IMYTQHFNIE KEEQKRIERN AKQRLQALKA
NDEEAYLKLL DQAKDTRITH LLRQTDGFLH QLASSVKAQQ RDAAERYGGD PNLRPDEPES
DDDSEDDDRT KKIDYYAVAH RVREEVTEQA NMLVGGRLKE YQVKGLQWMI SLYNNNLNGI
LADEMGLGKT IQTISLICYL IERKHQPGPY LVIVPLSTLT NWNLEFEKWA PSIARIVYKG
PPTTRKAQQD KIRQGRFQVL LTTYEYIIKD RPLLSKIKWF HMIVDEGHRM KNSNSKLSAT
ISQYYHTRFR LILTGTPLQN NLGELWAMLN FVLPNIFKSA TTFDDWFNTP FANTGGQDRM
ELNEEEQILV IRRLHKVLQP FLLRRLKKDV EKDLPDKTEK VIKCKFSALQ ARLYKEMLNN
NKLIVGDGKG GKTSARGLSN IIMQLRKLCN HPFVFDEIET VMNPQSISND LLWRTAGKFE
LLERILPKYK ATGHRVLMFF QMTAIMDIME DYLRYRGFQY LRLDGTTKAD ERSDLLRDFN
HPDSPYFMFL LSTRAGGLGL NLQTADTVII YDSDWNPHQD LQAQDRAHRI GQKNEVRILR
LITSTSVEEK ILERARYKLD MDGKVIQAGR FDNKSSETDR DAMLRTLLES ADLQESGDQE
EMDDEELNMI LARSENELAT FQKMDEERFH DPVYGTAPGC QAVPRLMAEN ELPDIYLADP
NAVEEEVEVV LGRGARERTK VKYDDGLTEE QWLMAVDDDD DSPEAAAARK QARKDKREQN
RLKRLANANP LTGSVENTPE GSRASSEEAE PEPEPEPETP VKKRGRKPNA KNEKRKADDE
DEPAPPAKKR RGPIGRPKAV AAADRAVSGG AASPAGSPKA SMTPQLRGRL QENLRKLYDG
LMTLEVDDPE PEDPEDKDKD EDDEPLKRII IGPFVKLPSK RDYGDYYVII QKPICMNQIH
ARIKKGEYHK LTDMQADIKL LCNNCRTYND DGSLLYADAN TIEEFFNAKI AETLAAHPEL
QALEPGGATK ASSEAPTTTN STPAPAATPL PKIKLVSNGV SLNKSANGSS NGNGEATNGT
STKTEDE
//
