ID A0A0F2QAG9_9CLOT Unreviewed; 506 AA.
AC A0A0F2QAG9;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=VR72_05745 {ECO:0000313|EMBL:KJS22541.1};
OS Clostridiaceae bacterium BRH_c20a.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae.
OX NCBI_TaxID=1629719 {ECO:0000313|EMBL:KJS22541.1, ECO:0000313|Proteomes:UP000033488};
RN [1] {ECO:0000313|EMBL:KJS22541.1, ECO:0000313|Proteomes:UP000033488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRH_c20a {ECO:0000313|EMBL:KJS22541.1};
RA Bagnoud A., Chourey K., Hettich R.L., de Bruijn I., Andersson A.F.,
RA Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT "Microbial metabolic network in the subsurface.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJS22541.1}.
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DR EMBL; LADT01000016; KJS22541.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F2QAG9; -.
DR STRING; 1629719.VR72_05745; -.
DR PATRIC; fig|1629719.3.peg.3510; -.
DR Proteomes; UP000033488; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 5..216
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 268..497
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 506 AA; 55841 MW; C5407E5B9F03DFEC CRC64;
MKTGKVFLIG AGPGDVKLIT LKGLECIKKA DVIVYDRLAN PRLLAHKMPK AQLIYVGKSP
DRHTLTQDEI NKVIVKEALE GKIVARLKGG DPFVFGRGGE EAEVLLESGI PFEIIPGITS
AISVPAYAGI PVTHRDFTST LTIITGNEDP TKEDTNINWD KLGQDPGTLI FLMGVGNLPK
IVEQLVKNGK TKNTPVALIR WGTRPEQQVV TGTLNNIVEE VTRAGLESPA IIIVGDVVKL
RNKLKWFENK PFFGKRILVT RSREQASDLS EKIEDLGGEA WEYPTIVIEE PLDFAPLDRA
ISNATEYDWI IFTSVNGVKA FFNRMAKLKI DIRKLGNVRF CAIGPKTKEA IEEKGLLVEY
VPEVFRAEAI VDGLKNTLQS GQKILLPRAD LARPVLLDSL QELNLQVDEA IAYRTVNNTE
DSKELLEKII NKEINVITFT SSSTVKNFIE LLEGNNAEEL LKGITVACIG PITAETAQEM
GLKVNITAEK YTIDGLISAL LNYFKN
//
