UniProt: A0A0F2T9L8

Database: UniProt
Entry: A0A0F2T9L8_STRR3

LinkDB:  A0A0F2T9L8_STRR3 
Original site:  A0A0F2T9L8_STRR3

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Ontology (8)   
   GO (8)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (50)   
   InterPro (28)   
   Pfam (11)   
   PROSITE (5)   
   SMART (6)   
All databases (60)   

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ID   A0A0F2T9L8_STRR3        Unreviewed;      3868 AA.
AC   A0A0F2T9L8;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Amino acid adenylation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VM95_29950 {ECO:0000313|EMBL:KJS58995.1};
OS   Streptomyces rubellomurinus (strain ATCC 31215).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=359131 {ECO:0000313|EMBL:KJS58995.1, ECO:0000313|Proteomes:UP000033699};
RN   [1] {ECO:0000313|EMBL:KJS58995.1, ECO:0000313|Proteomes:UP000033699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31215 {ECO:0000313|EMBL:KJS58995.1,
RC   ECO:0000313|Proteomes:UP000033699};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC       family. {ECO:0000256|ARBA:ARBA00029443}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJS58995.1}.
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DR   EMBL; JZKH01000083; KJS58995.1; -; Genomic_DNA.
DR   RefSeq; WP_045702645.1; NZ_JZKH01000083.1.
DR   PATRIC; fig|359131.3.peg.7491; -.
DR   OrthoDB; 5478077at2; -.
DR   Proteomes; UP000033699; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033699};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          32..455
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          952..1028
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2006..2081
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2096..2516
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3512..3589
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          920..941
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3868 AA;  406144 MW;  E97FBF0149FC72A2 CRC64;
     MNENANEDRL RRAMAAVLQL QQRNQELEHS RSEPIAIVSM ACRLPGGIAT PERYWEALAA
     GQDLIGPLPE RWADLDLYDP DPEAAGKSYA DQGGFLDGIE EFDAELFGVS PREALAMEPQ
     QRLVLETAWE ALERAGQRPG PLGTSRTGVY LGAMRSDYAT TQAGLEALDG YQGTGISSSV
     ISGRVSYTLG LQGPAVTVDT ACSSSLVAVH LACAALRSGE CDQALAGGVT VMNTPVLFVE
     SSRLRAMSPD GRSKSFGAGA DGGGWAEGAG MVLLKPLSAA RRDGDRILAV IRGSATNQDG
     RSQGLTAPNG PAQQRVIREA LAAARLTPAD VDAIEAHGTG TRLGDPIEAG ALAEVFGPGR
     DAARPLRLGS GKSNIGHSQA AAGVVGVIKM VLALQHERLP KTLHVEQPSP HIAWEGSGIE
     LLGEAADWPR GERPRRAGVS SFGISGTNAH LVLEEAPLDE APAEGADAVP AAGYPVLLSA
     QTPQALRAQA ARWADWLTEH PATPLLDLAR TAALHRTHLE HRAAVTAGSA AEAALGLRAL
     AEGAAPRELV QGRAAARGRA VFVFPGQGSQ WREMGRTLLD ESAVFRAAVE ECDAALRPHT
     GWSVRALLAG EGADLPDFER IDVLQPALFA VMIGLAETWR ALGVRPAAVV GSSQGEVPAA
     VVAGALSLQD GARLVALRSR ALLRECSGKG GMALVELPAE QAAALIEPYG GALSVAVINT
     ETSTVVSGDA EAIEALLAAM ADGDVYCRRI PSDAAGHSRH MDPILPGLAE QLAGLRPRPA
     AVPFYSTVTG TVLPGESLDA AYWCRNLRDT VRLDLALRAL TADGFGVFVE VSPHPVLGIP
     LTGATAANDG VVVGTLQRGR GGTDQLLQQL AALHSHGHPV DWAAVLGHRP AGRAVELPTY
     AFQRRRYWVE AQAPAAALRG SAPARPAVEP STQPSTQPDG LRARLAGLPA EDRARPLEEA
     VRREVAALLG TDEPVDAERR FRDLGMDSLM ALRLRNRLTE LTGAALPANL TLHHPNARAV
     TGYLLEHALG ELPAVAAGAR LTRAERRDEH PATEGQRRLW FLDQLTPGTA QYHVALKLRV
     ANPLDRTAFE RALAHLTGRH EALRTALRMR DGELVQAVSE VDSIPVRWED AEDAEAVARA
     EELTPFDLDG PSLARCRVLT LPGGEQLICL TVHHAVVDGW SLTVLLHELH DAYRAFADGT
     DLPAAPVEHH LGDFAAWEAA AALEGRFDEG LRHFAAELAG APRLEFPPGP ENADDQQPGG
     DTHYFTLPAE LRAEVEALAA RSSVTPYTVL VTAFAALLAR TCDQSDLTLG TVWANRQLPG
     TEGVVGFLVN TLPLRCDLTG EPTVSGLLTG MGEKVNAVAE HQGVPLTRLV QAAGGQRTGG
     QRTGDENPLF RAVFNYGSAE LPTVGEGADA WRLPTTGSPA GNVRGAAKFE LGLTLAPHGD
     GLRAELEYLP HVLDRAGAER LAAAYGQLLA EFARRPEAGL AELHALGAAE AAWLEELSGT
     VEPAGPARPT AYELILRQAE RTPDAVAVLA GGAELSYAEL LRRARALAVR LRAAGVGPGL
     PVGIHLPRGT DLVVAVLAVW TAGGAYLSLD PNYPAAHLDH MVEDSGLTVV LSDTPVERWS
     EGLTVLGMES TDGDGEFEGP AAGDLAYLIY TSGSTGRPKG VQIEHAQFAN FCRAMDERIG
     GGPGDTWLAV TSLSFDISTL ELLWTLTRGY RVVVAAGRTA DWAAHRGLGP THLQCTPSYA
     RMLLADAEGR ALIGGLRRML VGGEALDRGL ARKLAALCPG EVVNMYGPTE TTVWSATWTL
     DAAALERGEV SLGTPVLNTR FHVLDRSGRR VPRGTRGELW IGGHGVARGY HARPELTAER
     FTADPYATEP GARMYRTGDL VRYRADGSLE FCGRIDAQVK LRGHRIELGE VDTVAGEHPA
     VVECSAVVRE DTENDPRLTL YWVPAEGAEQ AEPQLAAHLA ERLPAHAVPG RLVRVSELPH
     TPNGKVDRNA LLRLPAPSAV VSPVADAGQD VQALVAAAWA RALNVAEVDP DRGFFDLGGT
     SMTALGAHRE LCAALGREFP LSAVFHHPTV RRLAAHLTGE TTATAPEVRT AVRPDEDAVA
     VVGLSCRLPG APDLAAFWAN LRAGVESISH FTEQELREAG VPEQLLVRPD YVRAKGYVDG
     ADLFDAAFFD CSPAEAEAMD PQHRLFLECA WEALEHAGLT PRGFDGRIAV FGGSGFGGYQ
     GADAEDMSAF YRAMIGGKND YLATRVAHKL DLRGPALTVQ TACSTGLVAA HLARESLLRG
     ESDAALVGAA SLTFPLKSGY LYQPGLVASP DGACRAFDAE GGGTVPGNGV GMLVLRRLSD
     AVAAGDTVYA VIRGSAVNND GADKVGFTAP SVAGQARVIA EAQAVAGVTP DTIGYVEAHG
     TATALGDPIE VQALQQVFGA AERTEPCALG SVKSNIGHAD ATAGIAGLIK AVLMLHHGEL
     VPSLHYTRPN PELGLDDSLF AVTTELREWS GEAGPRRAGV SSFGIGGTNA HLVLEQGPAG
     PAEAAPAEGV RPVVLSARDE TALRAQARRW AEHLAERPEL TPAAVAGPAA TRRTHFAARA
     SVLAGDHAEL VDALTALAEG RPHRLLSQGE AGRPGKAVFV FPGQGSQWPA MGRELLDRSP
     AFRAVVEACD RAFAPYLDWT VAELLAGTGA AATLPLDRLD VVQPAMYAMY VGLAAAWRER
     GLEPAAVVGH SQGEVAAAVV AGALTLDEGA RVVALRSRAL LGCAGRGEMA VVELPVDEVL
     GHLARHDGRI SLAAVNTAGS TAVSGDLDAI NDLLIDLDDQ DVICGKLNAA VASHSAQMDA
     ILPGLAAELA DLDPRTGDVP FYSTVTGGPL DGRFLDAAYW CRNLREPVRL DLAQRALLDA
     GHQVFVEVSP HPVLAHALTD NGLAAGAVVV DTLRRGHGGP EQLLRTLGVL HVHGYEVDWA
     AALDGAGPQV ELPGYAFQRK RYWAEPKAAK AAAVDSGDGE FWQAVTDGKT ERIAELLAAP
     EELKGGLEEL LPLLAAWHDG RQADAEVADW LYTERRVLAE PSPQPAALTG HWALVEPSGA
     QASTGLAEAL AAAGATVHRL PAGEDRAALA AALGALPELT GLLALPGDGA DERGFHRLLA
     LVQAVGDTGR PAPVWAVTRG ATALDGEDAP NHPQALVTGL GRVLTLEAPE RWGGTLDLPE
     QPYDGWQTAL VAALAAGDGE DEAALRPEGR YVRRLHRVEP AGTTGPAWRT SGTALITGGA
     GALGRQLARW LVERGTRRVV LATRTARSTP ELDALRQELA EHGAVLDLAA CDLADRERTA
     RLLADLDDAG AAEPLRVVAH LAGVSRMTAV DDLTPEAADE ELAGKARGAR HLHELLADRP
     LDAFLLYGSG ASLWGGAGQA AYGAANTALD ALARHRHARG LAATVVHWGG WAGGGMMTAE
     AERTYRSRGH RPIAADRALH ALGLVLAAGL PSAGVADIDW ATFAPLYAAA RPRPLVDTVP
     QARQALAPAE AAADDGAGHD LRRRLAGLDR TAALHLLTEL VTAETAPVLG LAPQAVPADQ
     PLQQLGMDSL MAVTIRGQLA RRTGLAVTTD TIVRAGSCRG IGGHLLERLL PDGAAPAEQG
     RAEDGWLRVL KPAAGRPRAR IFAMAGMGGT SAGHIPLARH LPADVELLAV QLPGRDGRSG
     EPPVTDMMLL ADHVAAAVSA RLDAPAVLYG HSQGSWLAWE LAHRLAGQPA APPLALVAAC
     GIPPQAEPTE GLRRLTGSAA VLDELPTAEA AALFAGLLPE QVLDSEELLT DYLVRLRADV
     TLAENHRAAL RHLDRAPLRI PVRAVAGTDD PVLPAEALDA WRPLTEGPYT RGGVPGTHAA
     PIENPAAMAA ELNEALAALA APATGTAN
//

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