ID A0A0F3RPC2_ORITS Unreviewed; 680 AA.
AC A0A0F3RPC2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=OTUT144_0935 {ECO:0000313|EMBL:KJW07019.1}, OTUT144_1607
GN {ECO:0000313|EMBL:KJW06355.1};
OS Orientia tsutsugamushi str. UT144.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Orientia.
OX NCBI_TaxID=1441384 {ECO:0000313|EMBL:KJW07019.1, ECO:0000313|Proteomes:UP000033580};
RN [1] {ECO:0000313|EMBL:KJW07019.1, ECO:0000313|Proteomes:UP000033580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UT144 {ECO:0000313|EMBL:KJW07019.1,
RC ECO:0000313|Proteomes:UP000033580};
RA Daugherty S.C., Su Q., Abolude K., Beier-Sexton M., Carlyon J.A.,
RA Carter R., Day N.P., Dumler S.J., Dyachenko V., Godinez A., Kurtti T.J.,
RA Lichay M., Mullins K.E., Ott S., Pappas-Brown V., Paris D.H., Patel P.,
RA Richards A.L., Sadzewicz L., Sears K., Seidman D., Sengamalay N.,
RA Stenos J., Tallon L.J., Vincent G., Fraser C.M., Munderloh U.,
RA Dunning-Hotopp J.C.;
RT "Genome Sequencing of Rickettsiales.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJW07019.1}.
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DR EMBL; LAOR01000132; KJW06355.1; -; Genomic_DNA.
DR EMBL; LAOR01000060; KJW07019.1; -; Genomic_DNA.
DR RefSeq; WP_045913614.1; NZ_LAOR01000132.1.
DR AlphaFoldDB; A0A0F3RPC2; -.
DR PATRIC; fig|1441384.3.peg.1942; -.
DR Proteomes; UP000033580; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 216..334
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 493..637
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 680 AA; 76514 MW; 32C234C91D090670 CRC64;
MGVIKYLSDT TINRIAAGEV VERPASVVKE LVENSIDSGA MKVDITLEKS GKNLIIVSDN
GCGMSAEDLE TAIERHTTSK LNENDIMNIN TFGFRGEALP SIASVSRMRI VTKSKLHDQA
YEINVHGGVK TKINSLPQLQ LTGTKIEVRD LFFATPARLK FLRSDRTEYI VCYDVVKRLA
ISYPHIAFSL VHDDRTILKL KASSQLSFDD ARKSRISEIL SKKFIDNAIS IGIERDELSI
TGFVSVPTYN KASAEDQLLF VNNRPVKDKL LMTAIRLAYQ GVLARERYPV VVIFISVAPH
FVDVNVHPTK SEVRFHDSSL VRGIIISAIK QALLNTSQLV SSIAASDANK YMKPQYDTDI
SEKVELSKDI KNIQQFPLQE LVNNFSKDFN VNLKSEFQDI QTNNLVSDNE QHKIESTTEN
IKSFSAFNQL GGNTESNQHM SILDDDKTKD DIIARNIASN EKVDVNKQEN IQKLNDSFCN
NFGDSYQLPL GLACAQFHGN YILAQTVDSL IIVDQHAAHE RITYENLRSQ FQAGQIIRQR
LLMPQVVILP DIVRVEKLCD KMQEILALGM GFERCGDVQV KVFEMPAILQ SVDIEAVVND
VADYLLTTDD HILLADMVEK ILQSYSCYHS IRSGRILTIA EMNSLLRQIE TTPFSGQCNH
GRPTYVRFEL KDIEKLFGRR
//
