ID A0A0F3RVN1_9LACO Unreviewed; 268 AA.
AC A0A0F3RVN1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Glyoxal reductase {ECO:0000313|EMBL:KJW13664.1};
GN ORFNames=VC81_01860 {ECO:0000313|EMBL:KJW13664.1};
OS Levilactobacillus spicheri.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Levilactobacillus.
OX NCBI_TaxID=216463 {ECO:0000313|EMBL:KJW13664.1, ECO:0000313|Proteomes:UP000033491};
RN [1] {ECO:0000313|EMBL:KJW13664.1, ECO:0000313|Proteomes:UP000033491}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LP38 {ECO:0000313|EMBL:KJW13664.1,
RC ECO:0000313|Proteomes:UP000033491};
RA Zheng J., Ganezle M.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJW13664.1}.
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DR EMBL; JZCR01000005; KJW13664.1; -; Genomic_DNA.
DR RefSeq; WP_045806454.1; NZ_JZCR01000005.1.
DR AlphaFoldDB; A0A0F3RVN1; -.
DR STRING; 216463.VC81_01860; -.
DR PATRIC; fig|216463.3.peg.2172; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000033491; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
FT DOMAIN 17..260
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 48
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 106
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 73
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 268 AA; 30281 MW; 7F77C332D7391A28 CRC64;
METTQLSNGV TIPMLGFGTY LIDSQDVPAA IQTAFDAGYR HLDCAHIYRN EPAVGAAIKA
SGIARDDLFV TSKVWNADQG YDKTLAAYDQ TLKDLQLDYL DLYLIHWPNE KNFDLTLDTW
RALETLYQQK KVRAIGVSNF SQDQLKQVFE MATVKPMVNQ IERHPYKVQA DLGKFDTDNG
IVNEGYSPIG HGHLILEDPV ITQLAQKYGK TPAQIVLRWQ IDTGFVVFPK SSKPARVKEN
FEISGFHLTA DEIQTINGLD RDEHLNYD
//
