ID A0A0F4GVH6_9PEZI Unreviewed; 2384 AA.
AC A0A0F4GVH6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=TI39_contig291g00014 {ECO:0000313|EMBL:KJY01415.1};
OS Zymoseptoria brevis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX NCBI_TaxID=1047168 {ECO:0000313|EMBL:KJY01415.1, ECO:0000313|Proteomes:UP000033647};
RN [1] {ECO:0000313|EMBL:KJY01415.1, ECO:0000313|Proteomes:UP000033647}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zb18110 {ECO:0000313|EMBL:KJY01415.1,
RC ECO:0000313|Proteomes:UP000033647};
RA Grandaubert J., Bhattacharyya A., Stukenbrock E.H.;
RT "RNA-seq based gene annotation and comparative genomics of four
RT Zymoseptoria species reveal species-specific pathogenicity related genes
RT and transposable element activity.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY01415.1}.
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DR EMBL; LAFY01000283; KJY01415.1; -; Genomic_DNA.
DR STRING; 1047168.A0A0F4GVH6; -.
DR OrthoDB; 2165012at2759; -.
DR Proteomes; UP000033647; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd01874; Cdc42; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037874; Cdc42.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR23501; MAJOR FACILITATOR SUPERFAMILY; 1.
DR PANTHER; PTHR23501:SF87; SIDEROPHORE IRON TRANSPORTER 2; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000033647};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..581
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1939..1975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1997..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2094..2237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2274..2309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2351..2378
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1539
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1608
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1653..1718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1760
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1952..1968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2001..2019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2097..2111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2181..2201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2286..2309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2384 AA; 257474 MW; 44DAE1CB3D211B19 CRC64;
MRSDLAARSR SVTDHNATFI GKREQSNGSL ERDPEIERRA SFMSERSHES AQAGVKRLEA
ISSTWSNAGL YVAYVGIALL AYATSLEGQT TGNLTIFATS AFKAHSLVST VMVVQGVVLS
IAKPPMSKIA DVFGRFEAFS LSICFYAVGF VQQAASNSVN TYAAAQVFYS TGSTGVQILI
QIFIADTSDL VNRALCSTIP SIPFLINVWI GPALAERILK NLNWRWGYGI WSIILPVAFL
PLALALVINQ RKAALRGILP ESPFAGKSAW GIIKNVWFEL DLFGLILISV AFSLILIPLT
LAAKAGWTNP NLISMLIVGV ACLVAIPFWE RNKTLAPRAF FPRAFWKNKT ITCGLGLSFF
YFMAFYLSVY PYFQSYLLVV KDLPLTQAGQ IVQTFTFTST ITSILVSLAI KYTKQYKKFM
VSGTVLYVIG LGLMLHYRTE TSTATTIVWT QVFLGVGGSL THVPAQLGVQ ASASHSEVAA
ATALFLTVLE IGGAVGSGIS GAIWTNSVPK KLALYLPPET ADQAAEIYGN ISLASGGWPM
GSPTRIAINR AYQETMTKIL SVAVCVALPC VVLSLMMTDY KLDEIDQGVK GVVIGASQGR
VDHGDGAVVA GPSNTRLLSA GEDSGDDEDV LGLRPQNSRS RLLDSAERRD SCVVVGDGAV
GKTCLLISYT TNKFPSEYVP TVFDNYAVTV MIGDEPYTLG LFDTAGQEDY DRLRPLSYPQ
TDVFLVCFSV TSPASFENVR EKWFPEVHHH CPGVPCLIVG TQTDLRDDGS VREKLAKQKM
QPVRKEDGEK MAKELGAVKY VECSALTQFK LKDVFDEAIV AALEPPQVKK TKHSAGSGQI
VATSVASRPR VLFRRFWSVS TVCGFNPWTE MHIREEKKYA KLRSNWAPLP DIPEMPEDEP
TISASAAASP NRNFLAESAL RTHRHKLASN AFYQQEFQRR KNTPPTMVHP AFRPSFDLYD
ISKKLPELDL ATNNTMSSQQ QTEKSSSPTP PHMQHDQHDS QRDSNCTTMS PFLNAGMMVP
SPPKLRRSSP RRGETKSLNS SPELRLAPTP NSTHVPTMRQ EVERRHEARM LDEVVDEYGD
VIPPPRTSSL VMVEEDEYNI RAQRVREGIK RRLSEASQSD ETVIRTEGAI TPATTKKTFF
QRMGISGRRS NTPEPSPSHM TSAPAPAHMA PKASAILMSP RVGFTAPSRL RTKNTGFFSR
KHRSADEDDT AAFTRARDFD DGSPPKVPAG AAASLGRKPP DAPFTSIVRS RSLKYIDHTS
PPTPPSKDTP PDGKTKSGKH TNISPSTSET PSRSVGFLSV DGDQSPSKGG TYAQRAIPRL
VTQPSTHSLR ASVVPNAMDA IDFADMKSRI SGLGLEGFSL PSETNRGGTP NIEYSPSVYS
PEWRNTPAME EFLSAEPPRV AAEPIRQRRY SMDTIGSDTG ASAFICPEPA GAPPREEKKE
DEEEEVTPTK SIPAMQQYQI SPFIGSTTTT TRGPRELSAM YNQLELMFDD DSDSDGDDDT
TLGRLAFIGS PMSQASAQPS PLRPPPSPPA RPARPARPAR LSPPAQLSET ELPEQLPAHL
TEHSPLAQLS EPYPPTQLPE PPSPALSEPY PSTQLPEPSS PARLSEPYPP VQLPESSSLM
QRSESPAMTK DAEPSSSAQL SEPYPPAQLP EPSSAVQPSE SPAPAQDTEL AATAQLPQPA
SAVQLSESPA PVQGSEIPSS AQIPEASPPV QKSDFSDPTT LALLLGLSQP AHFSQPSPPA
QVPASPPAQP STPEPAAKSS PEPSPRAQTP ELVPEPEPEL GAEEFPPRGP VIFSQLSSDG
KLQICEGIPK RPPPPAPRPR PWAVLQKAMP APTSPRPSPP GPYGNILYNA EGVQILGAQT
YVPPEGLQKR GAKKKSKWHH LPIMTCARPP KGPNISAAEW YELHDWDQNP PDLDWLFPAD
GDVYAGKCKT PPFSRIPCAL PDGEEDASKL PLPISGNTSP ASDKQVGSTD ESKAVKKDGW
SFEQRLYAAQ LHMRSAPVLT KQSGGGDTSK QTSPTRGMQY DSGIDVDPAK PRPRSAIPAS
PAAELDVGLS SDDPIENALA TAKSREAALE KLVAKAASHN RCLDQRLVSI DIDDSPSEQA
QWDRRMASLK KTDLPFGKSE SPRPVTSRRR GSQQSVKTPS VTAQSADTPS VNTSSVNAMS
SPHESPVAVR QGRKATPRKD HRRSTSSAKQ LREKNDWPIE SKAGLDESPT SDKSTSTAVP
KVKDNEEPVL DLLSKDITPE SLRSKDLLTP DLPGLVGPAF GTVLVPSPAT SPIAPTAAPA
TSPVAPKVAP TTTPTAASTT ATTTAATTAP TAASTAAPAA ASDVAPVVAS PAAPMEDAPN
VAEEGTLEAG MDMLKNVIDR QEEVMKEMMR QMHQMRTEMR KAGI
//
