ID A0A0F4J8S9_9ACTN Unreviewed; 383 AA.
AC A0A0F4J8S9;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein {ECO:0000313|EMBL:KJY30153.1};
DE EC=4.2.1.75 {ECO:0000313|EMBL:KJY30153.1};
GN ORFNames=VR44_21100 {ECO:0000313|EMBL:KJY30153.1};
OS Streptomyces katrae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68223 {ECO:0000313|EMBL:KJY30153.1, ECO:0000313|Proteomes:UP000033551};
RN [1] {ECO:0000313|EMBL:KJY30153.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL ISP-5550 {ECO:0000313|EMBL:KJY30153.1};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY30153.1}.
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DR EMBL; JZWV01000587; KJY30153.1; -; Genomic_DNA.
DR RefSeq; WP_045949117.1; NZ_JZWV01000587.1.
DR AlphaFoldDB; A0A0F4J8S9; -.
DR STRING; 68223.GCA_002028425_02778; -.
DR PATRIC; fig|68223.7.peg.8943; -.
DR OrthoDB; 213853at2; -.
DR Proteomes; UP000033551; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Lyase {ECO:0000313|EMBL:KJY30153.1}.
FT DOMAIN 275..368
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 275..368
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 383 AA; 40123 MW; 5EF8DA9677B9C286 CRC64;
MDDATHGPLA GFTVGVTAAR RADELIALLR RRGAAVVHAP ALRIVPLSDD GELMAATKEL
LDDPPDAVVA TTAIGFRGWI EAADGWGIGE RLLERLRTTE LLARGPKVKG AVRAAGLVET
WSPQSESLAE VLDRLLAGPV TGRRIALQLH GEPLPGFVEA LRDGGAEVVP VPVYRWMPPA
DLAPLDRLLD AVAVGALDAL TFTSAPAAAS LLSRAGERGL REAVLAALRG PVLAACVGPV
TALPLQGQGV ATVQPERFRL GPLVQLLCQE LPGRARVLPV AGHRLEIRGH AAVVDGGLRP
VPPAGMALLN ALARRPGWVV SRADLLRALP GAGRDEHAVE TAMARLRAAL GVPNLIQTVV
KRGYRLSLDP GDGEGWNGGR GVR
//
