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Database: UniProt
Entry: A0A0F4JL69_9ACTN
LinkDB: A0A0F4JL69_9ACTN
Original site: A0A0F4JL69_9ACTN 
ID   A0A0F4JL69_9ACTN        Unreviewed;       197 AA.
AC   A0A0F4JL69;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   11-DEC-2019, entry version 18.
DE   RecName: Full=Urease {ECO:0000256|SAAS:SAAS00312638};
DE            EC=3.5.1.5 {ECO:0000256|SAAS:SAAS00312638};
DE   Flags: Fragment;
GN   ORFNames=VR44_11160 {ECO:0000313|EMBL:KJY34920.1};
OS   Streptomyces katrae.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=68223 {ECO:0000313|EMBL:KJY34920.1, ECO:0000313|Proteomes:UP000033551};
RN   [1] {ECO:0000313|EMBL:KJY34920.1, ECO:0000313|Proteomes:UP000033551}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL ISP-5550 {ECO:0000313|EMBL:KJY34920.1,
RC   ECO:0000313|Proteomes:UP000033551};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000256|SAAS:SAAS01117045};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|SAAS:SAAS00607110};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000256|SAAS:SAAS00312627}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJY34920.1}.
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DR   EMBL; JZWV01000252; KJY34920.1; -; Genomic_DNA.
DR   EnsemblBacteria; KJY34920; KJY34920; VR44_11160.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000033551; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|SAAS:SAAS00321417};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00321440};
KW   Nickel {ECO:0000256|SAAS:SAAS00312631}.
FT   DOMAIN          18..134
FT                   /note="Urease_alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00449"
FT   NON_TER         197
FT                   /evidence="ECO:0000313|EMBL:KJY34920.1"
SQ   SEQUENCE   197 AA;  20483 MW;  2652C6C40F56AE36 CRC64;
     MSRPSRHSDH CAPGSRHIDP YEYATVHGPR AGDRVRLGDS GLVVRVESDA QKPGDEFLAG
     FGKTARDGLH LKAAAVRGTC DVVISNVLVI DAVLGIRKVS IGIREGRIHA IGRAGNPDTL
     EGVDVVVGTG TTMISGEGLI ATAGAVDTHV HLLSPRIMEA SLASGVTTVI GQEIGPAWGV
     GVNSPWALKH GFNAFDA
//
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