ID A0A0F4KTW2_9LACO Unreviewed; 866 AA.
AC A0A0F4KTW2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:KJY49488.1};
GN ORFNames=JG29_04520 {ECO:0000313|EMBL:KJY49488.1};
OS Bombilactobacillus mellis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Bombilactobacillus.
OX NCBI_TaxID=1218508 {ECO:0000313|EMBL:KJY49488.1, ECO:0000313|Proteomes:UP000033695};
RN [1] {ECO:0000313|EMBL:KJY49488.1, ECO:0000313|Proteomes:UP000033695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hon2 {ECO:0000313|EMBL:KJY49488.1,
RC ECO:0000313|Proteomes:UP000033695};
RA Ellegaard K.M., Tamarit D., Javelind E., Olofsson T., Andersson S.G.,
RA Vasquez A.;
RT "Comparative genomics of the lactic acid bacteria isolated from the honey
RT bee gut.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY49488.1}.
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DR EMBL; JXBZ01000003; KJY49488.1; -; Genomic_DNA.
DR RefSeq; WP_045922332.1; NZ_KQ033877.1.
DR AlphaFoldDB; A0A0F4KTW2; -.
DR STRING; 1218508.JG29_04520; -.
DR PATRIC; fig|1218508.4.peg.463; -.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000033695; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000033695}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 866 AA; 98035 MW; 6BA15CF2C6B0EA94 CRC64;
MPQKTKDTPM MQQYLNIKKD YPDAFLFYRI GDFYEMFYDD AIKGSQLLEL TLTARNKNAA
DPIPMCGVPH HAADSYIEVL VDKGYKVAIC EQLEDPKTAK GMVKRGIIKL VTPGTNLEDK
PNQSKENNYL AAIDPHNQQW GFAYTDLSTG EVKATVLTSL EQAKNELLNL RCKEVVVSPD
FASQWCQEIK DMGILVSQEE PQKEYAEVAF VNQGVQSQAA QNTIKYLISY LVETQKRSLN
HLQKAQFYAV NKYLQLDHNA QSNLELFRSL RTGEKSGTLA WLLDQTKTAM GSRLLKQWLQ
RPLLDVKQLT KRQNIVQVLL DNYFQRSSLQ DYLTKVYDLE RLAGRVAFGN VNGRDLIQLA
TSLVQVPKIK AILRDLQEPV INDLLKQIPD CQNVAQAITE AIVDDPPISV TEGNLIRPGY
NQQLDQYRLA MKNGKSWIAK MQVQEQQRTG IKNLKIGFNR VFGYYIEVTN ANKEQVPADR
YQRKQTLTNA ERYITPELKE KERLILEAEE KSTILEHELF SKLREQIKKQ IAPLQTLAQQ
LALLDVLQGF AVISENYHYV RPQFTKNNQV QIIDGRHPVV EKVLGKQKYI PNSIQMDKTT
SVLLITGPNM SGKSTYMRQM ALIVIMAQIG CFVPAQKAQL PIFDHIFTRI GAADDLISGN
STFMVEMMEA NDALQHATTH SLIIFDEIGR GTATYDGMAL AQAIVEYLNN QVHAKTMFST
HYHELTALAD QLDEVENVHV DATQENGKLV FLHKILPGPA DKSYGIHVAK LAGLPESLLK
RAQIILEDLE KTSAQKPAQP VEKTKDTTNK VAADKSYVKE QLSLFKEPET SPNQVLLQQL
KDANLMKMTP LDAMNLLAHL QDELVD
//
