ID A0A0F4LL52_9LACO Unreviewed; 287 AA.
AC A0A0F4LL52;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:KJY59330.1};
GN Name=mmsB {ECO:0000313|EMBL:KJY59330.1};
GN ORFNames=JF76_00850 {ECO:0000313|EMBL:KJY59330.1};
OS Lactobacillus kullabergensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1218493 {ECO:0000313|EMBL:KJY59330.1, ECO:0000313|Proteomes:UP000033533};
RN [1] {ECO:0000313|EMBL:KJY59330.1, ECO:0000313|Proteomes:UP000033533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Biut2 {ECO:0000313|EMBL:KJY59330.1,
RC ECO:0000313|Proteomes:UP000033533};
RA Ellegaard K.M., Tamarit D., Javelind E., Olofsson T., Andersson S.G.,
RA Vasquez A.;
RT "Comparative genomics of the lactic acid bacteria isolated from the honey
RT bee gut.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY59330.1}.
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DR EMBL; JXBY01000001; KJY59330.1; -; Genomic_DNA.
DR RefSeq; WP_045927322.1; NZ_KQ033870.1.
DR AlphaFoldDB; A0A0F4LL52; -.
DR STRING; 1218493.JF76_00850; -.
DR PATRIC; fig|1218493.3.peg.91; -.
DR HOGENOM; CLU_035117_1_0_9; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000033533; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 287 AA; 31020 MW; 3B1ED68759EB64C2 CRC64;
MKIGFIGTGV MGNAICLNLL KADHQLWVYN RTKSKTDNLV AQGATWCENP KAVVEHADTI
FTIVGFPKDV EQVYFGDNGI LQADVKGKNL VDMTTSKPAL AQKIFAAGEK QGAKVLDAPV
SGGDLGAKNG TLTIMVGGDE SAYQNLEPVF KDFGKQVHFF GPAGAGQNTK MANQIMIAGT
MTGMTEMLVY AKKAGLDLEA VLKTVGAGSA ANWSLSNYGP RVLKGDYTPG FFSKHFLKDL
RIALETAKEM KIELPATEEA KKLYETLVDE KHLGDLGTQG LIKLWWQ
//
