ID A0A0F4LZ01_9LACO Unreviewed; 923 AA.
AC A0A0F4LZ01;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=JG30_02560 {ECO:0000313|EMBL:KJY62801.1};
OS Bombilactobacillus mellifer.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Bombilactobacillus.
OX NCBI_TaxID=1218492 {ECO:0000313|EMBL:KJY62801.1, ECO:0000313|Proteomes:UP000033558};
RN [1] {ECO:0000313|EMBL:KJY62801.1, ECO:0000313|Proteomes:UP000033558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bin4 {ECO:0000313|EMBL:KJY62801.1,
RC ECO:0000313|Proteomes:UP000033558};
RA Ellegaard K.M., Tamarit D., Javelind E., Olofsson T., Andersson S.G.,
RA Vasquez A.;
RT "Comparative genomics of the lactic acid bacteria isolated from the honey
RT bee gut.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY62801.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXJQ01000003; KJY62801.1; -; Genomic_DNA.
DR RefSeq; WP_046315508.1; NZ_KQ034028.1.
DR AlphaFoldDB; A0A0F4LZ01; -.
DR STRING; 1218492.JG30_02560; -.
DR PATRIC; fig|1218492.5.peg.372; -.
DR HOGENOM; CLU_005831_3_0_9; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000033558; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR046818; MmeI_C.
DR InterPro; IPR046819; MmeI_hel.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046817; MmeI_N.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20467; MmeI_C; 1.
DR Pfam; PF20465; MmeI_hel; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20464; MmeI_N; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:KJY62801.1};
KW Hydrolase {ECO:0000313|EMBL:KJY62801.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:KJY62801.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033558};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..186
FT /note="MmeI-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20464"
FT DOMAIN 198..276
FT /note="MmeI-like helicase spacer"
FT /evidence="ECO:0000259|Pfam:PF20465"
FT DOMAIN 366..619
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 635..838
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
FT DOMAIN 841..919
FT /note="MmeI-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20467"
SQ SEQUENCE 923 AA; 106409 MW; 9B6AC80A36D4C76A CRC64;
MDVTTQKRNA KKFIENWKNR GHEKQDSQSF WLALLRDVVG VEKPENFIDF EEKVQLEHDS
FIDAYIDQTH VMIEQKSSSK DLDKPIRQSD GILLTPFQQA QRYSAGLSYS KRPRWIVTCN
FKEFRVYDME HPNSEPDKIE LKDLATEYYR LEFLVDKSNQ HLEKEKQVSI SAGELVGQIY
DELLKQYKNP DSEYSQKSIN QLCVRIVFCL YAEDSGIFGR KNMFHDYLED FDVHHFRAAL
INLFKVLDTK VEDRDPYLAD DEPKLAEFPY VNGGMFSEKD IEIPSFTDEL KDLLLNKASN
EFDWSEISPT IFGAVFESTL NPETRHQGGM HYTSVENIHK VIDPLFLDDL KDEFNEIKKT
KQPATLKKKA KAFQDKIANL TFMDPACGSG NFLTETYLQL RKLENEAIKL IYPNPILDTD
ISKSIIKVSI KQLYGIEIND FAVSVAKTAL WIAESQMLEE TKDIFYANWD FLPLKTYSHI
HEGNALTMDW NKVLSNYACH YIMGNPPFIG TKYENENQKT DINNLNHNLK GIDYVSGWYY
KAIEYIQDTK IECCYVSTNS ITQGQQVAVL WSILLKLGIK INFAYRTFIW TSEASQKAHV
HCVIVGFSLF DRKRKFLYEN GLVSKVSTIN PYLVDGPNIL IKSRSKPLSN VLEMVKGSQP
TDGGNLILNE SEKSELIKSE PKSKKYIRRY MGANDLIKNK CRYCLWLKDC PPNDLKNMPL
ILKRLKLVQS SRLSSKKAAT QKWAKKPALF TEDRQPNSDY LMVPVVSSEQ RRYIPMAFVS
KEVIANTNAQ MIPNAGLYEF AILESNMHMG WMRTVAGRMK SDYAYSAKIV YNNFPWPSPT
NEQKEKIKNT AQEILDARAL YPDASLADLY DTLTMPPELL KAHQNNDRAV MEAYGLPVKS
TTESDAVAFL FNLYSKLTKK DEN
//