ID A0A0F4NEJ0_9VIBR Unreviewed; 401 AA.
AC A0A0F4NEJ0;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Bcr/CflA family efflux transporter {ECO:0000256|RuleBase:RU365088};
GN ORFNames=TW81_17930 {ECO:0000313|EMBL:KJY81505.1};
OS Vibrio galatheae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=579748 {ECO:0000313|EMBL:KJY81505.1, ECO:0000313|Proteomes:UP000033673};
RN [1] {ECO:0000313|EMBL:KJY81505.1, ECO:0000313|Proteomes:UP000033673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2757 {ECO:0000313|EMBL:KJY81505.1,
RC ECO:0000313|Proteomes:UP000033673};
RX PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT "Genome mining reveals unlocked bioactive potential of marine Gram-negative
RT bacteria.";
RL BMC Genomics 16:158-158(2015).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU365088}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU365088}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC family. {ECO:0000256|ARBA:ARBA00006236, ECO:0000256|RuleBase:RU365088}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY81505.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXXV01000037; KJY81505.1; -; Genomic_DNA.
DR RefSeq; WP_045957117.1; NZ_JXXV01000037.1.
DR AlphaFoldDB; A0A0F4NEJ0; -.
DR STRING; 579748.TW81_17930; -.
DR PATRIC; fig|579748.3.peg.3699; -.
DR OrthoDB; 9814303at2; -.
DR Proteomes; UP000033673; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd17320; MFS_MdfA_MDR_like; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00710; efflux_Bcr_CflA; 1.
DR PANTHER; PTHR23502:SF132; BICYCLOMYCIN RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR23502; MAJOR FACILITATOR SUPERFAMILY; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU365088};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365088};
KW Reference proteome {ECO:0000313|Proteomes:UP000033673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365088};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365088};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365088}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 53..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 142..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 221..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 291..309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 315..339
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365088"
FT DOMAIN 18..401
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 401 AA; 42892 MW; F64362B74298649C CRC64;
MSERTLDQTS APQISFLLFL VLGAIGALTP LAIDMYLPAM PTIAKDLGVA EGAVQITLTA
YTAGFAIGQL IHGPLADSYG RRPVLILGVL FFGIAAVVSA TTTGIEALTW VRTAQGFAGA
AAAVVIQAVV RDMFDREDFS RAMSFVTLVI TIAPLIAPMI GGYVAVWFGW RAIFWILAMF
AVVVIGLVMW KIPETLSSEN KQPFRIRNTL RNYLRLSRNP VAMGLIFSGA FSFAGMFAFL
TAGSFVYIDI YGVPPEQFGY LFGLNIVAMI IMTSINGRLV KKVGSHAMLR FGLFVQLIAG
IGLFVTWLLD FGLWGTVIFV VMFIGTLSTI GSNSMGLLLS GYPTMAGTAS SLAGTLRFGT
GSIVGAVVAM MPGGVTWPMI TVMSACSVIS VACYWIFGRK A
//
