ID A0A0F4NJL1_9VIBR Unreviewed; 331 AA.
AC A0A0F4NJL1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000256|HAMAP-Rule:MF_01004};
GN Name=btuC {ECO:0000256|HAMAP-Rule:MF_01004};
GN ORFNames=TW81_10315 {ECO:0000313|EMBL:KJY83375.1};
OS Vibrio galatheae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=579748 {ECO:0000313|EMBL:KJY83375.1, ECO:0000313|Proteomes:UP000033673};
RN [1] {ECO:0000313|EMBL:KJY83375.1, ECO:0000313|Proteomes:UP000033673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2757 {ECO:0000313|EMBL:KJY83375.1,
RC ECO:0000313|Proteomes:UP000033673};
RX PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT "Genome mining reveals unlocked bioactive potential of marine Gram-negative
RT bacteria.";
RL BMC Genomics 16:158-158(2015).
CC -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC vitamin B12 import. Involved in the translocation of the substrate
CC across the membrane. {ECO:0000256|HAMAP-Rule:MF_01004}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC {ECO:0000256|HAMAP-Rule:MF_01004}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01004};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000256|ARBA:ARBA00007935,
CC ECO:0000256|HAMAP-Rule:MF_01004}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY83375.1}.
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DR EMBL; JXXV01000016; KJY83375.1; -; Genomic_DNA.
DR RefSeq; WP_045955614.1; NZ_JXXV01000016.1.
DR AlphaFoldDB; A0A0F4NJL1; -.
DR STRING; 579748.TW81_10315; -.
DR PATRIC; fig|579748.3.peg.2123; -.
DR OrthoDB; 9055647at2; -.
DR Proteomes; UP000033673; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR CDD; cd06550; TM_ABC_iron-siderophores_like; 1.
DR Gene3D; 1.10.3470.10; ABC transporter involved in vitamin B12 uptake, BtuC; 1.
DR HAMAP; MF_01004; BtuC; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR023691; ABC_transptr_BtuC.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; FERRIC ENTEROBACTIN TRANSPORT SYSTEM PERMEASE PROTEIN; 1.
DR PANTHER; PTHR30472:SF29; VITAMIN B12 IMPORT SYSTEM PERMEASE PROTEIN BTUC; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; ABC transporter involved in vitamin B12 uptake, BtuC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01004};
KW Reference proteome {ECO:0000313|Proteomes:UP000033673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01004};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01004}; Transport {ECO:0000256|HAMAP-Rule:MF_01004}.
FT TRANSMEM 17..42
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 62..83
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 238..265
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
FT TRANSMEM 306..325
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01004"
SQ SEQUENCE 331 AA; 35511 MW; 2F858F0BD2D4AA1B CRC64;
MEFTQLLERR RQRWTRFALL FTLFLVFISG LYLVVGEVFI SPLEELSALE EQLILQLRLP
RLLAALAVGA SLAVSGAVLQ VLLGNVLAEP GVLGISGGAS VLMVLVLFFA PALATPFGFM
LAAVIGALAF TILLVFIAKS MCLTTTRLLL VGVALGILSG AVVTWAFYFS DDLSLRQLMY
WLMGSIGAAS WYHHLLSLIL LPVLIWLCCK GSLLDKLMMG EQHAKQLGVD VDQARWQLIC
AVSILVGGAV ALGGVIGFVG LVVPHLLRLA LGSENRYLLP ISALAGAILV VLADLIARTA
LDSAELPLGV VTTSIGAPIF IWMLVSHHDS R
//
