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Database: UniProt
Entry: A0A0F4QDE4_9GAMM
LinkDB: A0A0F4QDE4_9GAMM
Original site: A0A0F4QDE4_9GAMM 
ID   A0A0F4QDE4_9GAMM        Unreviewed;       491 AA.
AC   A0A0F4QDE4;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=TW86_21930 {ECO:0000313|EMBL:KJZ04662.1};
OS   Halomonas sp. S2151.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=579478 {ECO:0000313|EMBL:KJZ04662.1, ECO:0000313|Proteomes:UP000033642};
RN   [1] {ECO:0000313|EMBL:KJZ04662.1, ECO:0000313|Proteomes:UP000033642}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2151 {ECO:0000313|EMBL:KJZ04662.1,
RC   ECO:0000313|Proteomes:UP000033642};
RX   PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA   Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT   "Genome mining reveals unlocked bioactive potential of marine Gram-
RT   negative bacteria.";
RL   BMC Genomics 16:158-158(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJZ04662.1}.
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DR   EMBL; JXYB01000136; KJZ04662.1; -; Genomic_DNA.
DR   EnsemblBacteria; KJZ04662; KJZ04662; TW86_21930.
DR   PATRIC; fig|579478.3.peg.4563; -.
DR   Proteomes; UP000033642; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033642};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033642}.
FT   DOMAIN      188    404       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      399    468       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     196    203       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      350    370       {ECO:0000256|SAM:Coils}.
FT   COILED      468    488       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   491 AA;  54920 MW;  520C7411871698E0 CRC64;
     MSLALWQQCL QTLQDELSSQ QFNTWIRPLQ AEEGESNQLR LLAPNRFVRD WVSDKYAKRI
     SELMRELAPA KPPKVMLTVG SRRAAPAPPQ TRELGDPVSA APARSAAVHT SSRGDVGDER
     EVDRLRDEGG EAPVTRPPGG ERQVQVEGSL KHSSGLNPNF TFETFVEGKS NQLARAASRQ
     VSENPGGAYN PLFLYGGVGL GKTHLMHAVG NALAGRRENA RVVYLHSERF VADMVKALQL
     NAINDFKRFY RSVDALLIDD IQFFAGKERS QEEFFHTFNA LLEGGQQMIL TSDRYPKEIS
     GVEERLKSRF GWGLTVAIEP PELETRVAIL MKKADQAKVD LPHDAAFFIA QKIRSNVREL
     EGALKKVIAD SHFMGKSITQ DFIRESLKDL LALQDKQVGV DNIQRTVAEY YKIKLADLLS
     KRRSRSVARP RQVAMALAKE LTNHSLPEIG DAFGGRDHTT VLHACRKVQA LQEESADIRE
     DYKNLLRLLT S
//
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