ID A0A0F4RQN8_9RHOB Unreviewed; 630 AA.
AC A0A0F4RQN8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Propionyl-CoA synthetase {ECO:0000313|EMBL:KJZ21052.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:KJZ21052.1};
GN Name=prpE {ECO:0000313|EMBL:KJZ21052.1};
GN ORFNames=TW80_07575 {ECO:0000313|EMBL:KJZ21052.1};
OS Loktanella sp. S4079.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Loktanella.
OX NCBI_TaxID=579483 {ECO:0000313|EMBL:KJZ21052.1, ECO:0000313|Proteomes:UP000033741};
RN [1] {ECO:0000313|EMBL:KJZ21052.1, ECO:0000313|Proteomes:UP000033741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4079 {ECO:0000313|EMBL:KJZ21052.1,
RC ECO:0000313|Proteomes:UP000033741};
RX PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT "Genome mining reveals unlocked bioactive potential of marine Gram-negative
RT bacteria.";
RL BMC Genomics 16:158-158(2015).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJZ21052.1}.
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DR EMBL; JXYE01000002; KJZ21052.1; -; Genomic_DNA.
DR RefSeq; WP_045997093.1; NZ_JXYE01000002.1.
DR AlphaFoldDB; A0A0F4RQN8; -.
DR STRING; 579483.TW80_07575; -.
DR PATRIC; fig|579483.3.peg.1552; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000033741; Unassembled WGS sequence.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Ligase {ECO:0000313|EMBL:KJZ21052.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033741}.
FT DOMAIN 3..57
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 64..444
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 510..588
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 630 AA; 68783 MW; D6324609F91D5541 CRC64;
MGYAEVYKGW QDDPEGFWME QAKAIDWDSP PTKALFGDNA PFYEWFADAK VNTCYNAVDR
HVENGHGEQT AIIYDSPIAH TKREISYVEL RNRVASLAGA LRAKGVEKGD RVIIYMPMIP
EALEAMLACA RLGAIHSVVF GGFAANELAV RIDDAKPKAI IAASCGMEPG RVVHYKPLLD
GAIEMAAHKP EFCVIFQREQ EVAELIPGRD YNWHGFQYGV TPAECVPVEG NHPAYILYTS
GTTGAPKGVV RPTAGHLVAL NWTMKNIYNV DPGDVFWAAS DVGWVVGHSY ICYAPLIHGN
TTIVFEGKPI GTPDAGTFWR VIQEHNVKSF FTAPTAFRAV KREDPTGEFV KKYDLSCLNA
IYLAGERADP DTINWTQEKT GKPVYDHWWQ TETGYAIAGN PVGIEPLPVK IGSPTVPMPG
YDVQILDDGG HPVAAGELGA IAIKLPLPPG TLPTLWNAQD RFEKSYLTTF PGYYETGDAG
MIDEDGYVYI MARTDDVINV AGHRLSTGAM EEVLANHPDV GECAVIGVTD QLKGQLPMGF
VCLNKGCTRS HEDITKEVVK SVRDTIGPVA AFKLVAVVDR LPKTRSGKIL RGTMVKIADN
AEFKMPATID DPAILDEIKA ALRPLGYAGA
//
