ID   A0A0F4YL03_TALEM        Unreviewed;       439 AA.
AC   A0A0F4YL03;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=GTP cyclohydrolase II {ECO:0000313|EMBL:KKA18551.1};
DE            EC=3.5.4.25 {ECO:0000313|EMBL:KKA18551.1};
GN   ORFNames=T310_7487 {ECO:0000313|EMBL:KKA18551.1};
OS   Rasamsonia emersonii CBS 393.64.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Rasamsonia.
OX   NCBI_TaxID=1408163 {ECO:0000313|EMBL:KKA18551.1, ECO:0000313|Proteomes:UP000053958};
RN   [1] {ECO:0000313|EMBL:KKA18551.1, ECO:0000313|Proteomes:UP000053958}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 393.64 {ECO:0000313|EMBL:KKA18551.1,
RC   ECO:0000313|Proteomes:UP000053958};
RA   Heijne W.H., Fedorova N.D., Nierman W.C., Vollebregt A.W., Zhao Z., Wu L.,
RA   Kumar M., Stam H., van den Berg M.A., Pel H.J.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC       {ECO:0000256|ARBA:ARBA00008131}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKA18551.1}.
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DR   EMBL; LASV01000443; KKA18551.1; -; Genomic_DNA.
DR   RefSeq; XP_013325163.1; XM_013469709.1.
DR   AlphaFoldDB; A0A0F4YL03; -.
DR   STRING; 1408163.A0A0F4YL03; -.
DR   GeneID; 25319759; -.
DR   OrthoDB; 46806at2759; -.
DR   Proteomes; UP000053958; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:UniProtKB-EC.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR   CDD; cd00641; GTP_cyclohydro2; 1.
DR   Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR   InterPro; IPR022163; GTP_CH_N.
DR   InterPro; IPR032677; GTP_cyclohydro_II.
DR   InterPro; IPR000926; RibA.
DR   InterPro; IPR036144; RibA-like_sf.
DR   PANTHER; PTHR47259; -; 1.
DR   PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR   Pfam; PF12471; GTP_CH_N; 1.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   SUPFAM; SSF142695; RibA-like; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KKA18551.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053958}.
FT   DOMAIN          28..220
FT                   /note="GTP cyclohydrolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12471"
FT   DOMAIN          261..375
FT                   /note="GTP cyclohydrolase II"
FT                   /evidence="ECO:0000259|Pfam:PF00925"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   439 AA;  48875 MW;  00E4C89D397C3DDE CRC64;
     MLDTDAPADV DRHPKEEPTT PPKSPHSKHI TLTTYPGQSG IDPVPLQWGA PDAKSRGPII
     VSRHPSMLKR RNAMGAHGGS YSIYNALAIA AGDLPTDFRP DFTNTEPTFK FPWQPSWADP
     TKIVSLDPYG HDIVAQFKDY LDAGWDIRPT MAVTRANMKL AEIEKAVSEG KLAVDGNIVV
     DETGEVRVTK VAVEPVWYLP GVAARFGVDE GTLRRTLFEQ TGGSYPELIT RPDLKVFLPP
     IGGMTVYIFG PPERVSDENV RLALRIHDEC NGSDVFQSDI CTCRPYLAFG IQEAVREAQN
     GGSGVVIYFR KEGRALGEVV KYLVYNARKR GGDTADKYFT RTENIAGVRD MRFQALMPDI
     LHWLGIKKID RMLSMSNMNI LSEMIPKDSR VEIDAKINAG YFTTGKQYTM EELAQIKGRG
     WEKWEDVTSL IDAIGIGYY
//