ID A0A0F4YRF1_TALEM Unreviewed; 754 AA.
AC A0A0F4YRF1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=T310_5800 {ECO:0000313|EMBL:KKA20188.1};
OS Rasamsonia emersonii CBS 393.64.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Rasamsonia.
OX NCBI_TaxID=1408163 {ECO:0000313|EMBL:KKA20188.1, ECO:0000313|Proteomes:UP000053958};
RN [1] {ECO:0000313|EMBL:KKA20188.1, ECO:0000313|Proteomes:UP000053958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 393.64 {ECO:0000313|EMBL:KKA20188.1,
RC ECO:0000313|Proteomes:UP000053958};
RA Heijne W.H., Fedorova N.D., Nierman W.C., Vollebregt A.W., Zhao Z., Wu L.,
RA Kumar M., Stam H., van den Berg M.A., Pel H.J.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent DNA helicase important for chromosome
CC transmission and normal cell cycle progression in G(2)/M (By
CC similarity). May have a role in changing DNA topology to allow the
CC loading of proteins involved in maintaining sister chromatid cohesion
CC in the vicinity of the centromeres (By similarity). Has a specific role
CC in chromosome segregation during meiosis II.
CC {ECO:0000256|ARBA:ARBA00025396}.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKA20188.1}.
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DR EMBL; LASV01000282; KKA20188.1; -; Genomic_DNA.
DR RefSeq; XP_013326800.1; XM_013471346.1.
DR AlphaFoldDB; A0A0F4YRF1; -.
DR STRING; 1408163.A0A0F4YRF1; -.
DR GeneID; 25318140; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000053958; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd17969; DEAHc_XPD; 1.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 1.10.275.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KKA20188.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KKA20188.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053958}.
FT DOMAIN 7..245
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 722..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 209..261
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 739..754
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 86193 MW; AA1C9F504E8B1DDB CRC64;
MKFFIDDLPV LFPYPRIYPE QYAYMCDLKK TLDAGGHCVL EMPSGTGKTI SLLSLIVAYQ
QFYPEHRKLI YCSRTMSEIE KALTELKALM KYRSQQLGYT EDFRALGLTS RKNLCLHPSV
KREKSGTVVD ARCRSLTAGF VKEKKERGED VELCIYHEMP FCNVIIYSYH YLLDPKIAER
VSRELSKDCI VVFDEAHNID NVCIESLSID ITEDSLRKAS RSAANLERKI GEMKSTDAER
LQNEYAKLVE GLREAEEARD EEQFIANPIL PDDLLKEAVP GNIRRAEHFV AFLKRFIEYL
KMRMKVTHTI SETPPSFLAH LKDLTFIERK PLRFCAERLT SLVRTLELLN LEDYHSLQEV
ATFATLVATY DKGFLLILEP FESETATVPN PVLHFTCLDA AIAIKPVFDR FSSVIITSGT
LSPLEMYPKM LGFTAVLQES YSMTLARRSF LPMIVTRGSD QAQISSSFQI RNDPGVVRNY
GNLLLEFCRI TPDGIVVFFP SYLYMESIIS MWQGMGILDQ IWNYKLILVE TPDSQESSLA
LETYRTACCN GRGAVLLCVA RGKVSEGIDF DHHYGRAVIC IGVPFQYTES RILKARLEFL
RENYRIREND FLSFDAMRHA AQCLGRVLRG KDDYGIMVLA DRRFQKKRTQ LPKWISQALL
ESETNLSTDM AVATAKNFLR TMAQPFKAKD QEGISTWSLA ELEQHVAKQK EEQARLMREA
AANDQMNNGA HGATVQREEF DDDIDEELMM LDAD
//
