ID A0A0F4YS92_TALEM Unreviewed; 1137 AA.
AC A0A0F4YS92;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Sodium/calcium exchanger protein {ECO:0000313|EMBL:KKA21137.1};
GN ORFNames=T310_4850 {ECO:0000313|EMBL:KKA21137.1};
OS Rasamsonia emersonii CBS 393.64.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Rasamsonia.
OX NCBI_TaxID=1408163 {ECO:0000313|EMBL:KKA21137.1, ECO:0000313|Proteomes:UP000053958};
RN [1] {ECO:0000313|EMBL:KKA21137.1, ECO:0000313|Proteomes:UP000053958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 393.64 {ECO:0000313|EMBL:KKA21137.1,
RC ECO:0000313|Proteomes:UP000053958};
RA Heijne W.H., Fedorova N.D., Nierman W.C., Vollebregt A.W., Zhao Z., Wu L.,
RA Kumar M., Stam H., van den Berg M.A., Pel H.J.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKA21137.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LASV01000201; KKA21137.1; -; Genomic_DNA.
DR RefSeq; XP_013327749.1; XM_013472295.1.
DR AlphaFoldDB; A0A0F4YS92; -.
DR STRING; 1408163.A0A0F4YS92; -.
DR GeneID; 25317197; -.
DR OrthoDB; 5482417at2759; -.
DR Proteomes; UP000053958; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053958};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 962..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1030..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..381
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 967..1129
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 98..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 125365 MW; 55CC18EF5D753052 CRC64;
MAVLHVAAQF SIVLITCRCL LSHAVGCIIL CRTPLLAWRR ARADINHFRV WHEPVATLTL
RSLANLMPAD LQASRPSQVI GLEGRSNCST FHRSGSFRQH RGNSVHDAPV MRSPPAPFSR
PSVTVRTRKN GPYSAHAFFL TIIAISLLVV LSWGTRGSGE LRSLHPSLGK RAVIPDGRTG
PVSESTRAPA EELECRLVRH AEDQCAFVRS NCPDEEGLFS YLQFYYCTLR HVQPLAFIIL
VLWLSLLFST IGIAASDFLC INLSTIASIL GMSESLTGVT FLAFGNGSPD VFSTFAAMSS
NSGSLAVGEL IGAACFITAV VAGSMALVRP FRVARRSFVR DVGYFIIAAG FSMIALADGE
LHVWESTTMI GLYLFYVLMV VLWHWYLTRQ RRRYERDLAA RAHFHIPERE ELDLQERAPD
DDPIAGETRT PLHGSSTADF EALERTVWPA WKDDEDDETH NRYLAEIREN MHVSRPTPTR
RRPTVNAIRP SLVGALEFQS VLSSLRRSRN LLNDRIDLQR YTDDPHQAPS RHVDNLSVLS
HPPENTGAGQ EEGRINRHRS VSMNDAPPLR LDTSVVDKKG SPSRNIASYT DPGETSKTPD
AGASPQAEFL RIDSSAMLTA SPTSSGFPSR SQSPVPAGRT QTQSSDHLTV PNDLFRTPNY
QASPRRLGVS PGGVSPLSTA QVPQISISSE PEASESPSVP FPPFSDTSPS PSSRELSIHL
PPTSVSSSEL LEADDHFIED MDRATKRWRW WPYWFLPPPW LLMSTLFPTL YDWQAKNVWE
KLLGFVAAPS VFLLTITIPV VDPKRSDSES DSDFSQQSTA NDENERRPLV RLPDDSPLLR
PQSSEFSEAQ RNQARGSKKG NHAHPSTMRP RFDSETPVRQ PQSSADASTP PAREWHRWLV
SIQLFTAPLF IILVGWLNLD PDRVPRKLLL PILSCLPVSL ICATLLNLLL RGRAYPQPPN
QLRPFLAFLG FVVGICWIAT IANEVVSLLK TLGVILDISD SLLGLTVFAV GNSLGDLVAD
ITVARLGYPV MALSACFGGP MLNILLGIGV GGLYMTLHPK PYISTTAVPI HAVVTDPYEI
TISKSLFISG VTLLVTLVGL LIIVPLNHWR MDRKIGCGLV ALWSISTLAN VITEIAA
//
