ID A0A0F4ZL59_9PEZI Unreviewed; 2546 AA.
AC A0A0F4ZL59;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KKA30866.1};
GN ORFNames=TD95_000725 {ECO:0000313|EMBL:KKA30866.1};
OS Thielaviopsis punctulata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Ceratocystidaceae; Thielaviopsis.
OX NCBI_TaxID=72032 {ECO:0000313|EMBL:KKA30866.1, ECO:0000313|Proteomes:UP000033483};
RN [1] {ECO:0000313|EMBL:KKA30866.1, ECO:0000313|Proteomes:UP000033483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-DP1 {ECO:0000313|EMBL:KKA30866.1};
RA Radwan O., Al-Naeli F.A., Rendon G.A., Fields C.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKA30866.1}.
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DR EMBL; LAEV01000214; KKA30866.1; -; Genomic_DNA.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000033483; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000033483};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..427
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2462..2539
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2546 AA; 276495 MW; 57EA58CE039F8727 CRC64;
MPCGESPVPP VAVVGFGMRL PGKISTSEDL WSLIVNKRDA RAPIPASRWD AKTWKNNHAT
DHGYFLDEET DLKKFDSSMF SMSRTELESL DPRQRILLEV VWECMENAGQ KEWRGTRTGV
FVGSFSQDWM EMTARDPLMK GVFRIYNGAD FYLPNRISYE YNLSGPSVAV QAACASGLTA
VHEACTALYN GECKGAIAAG TSILLSPLVV EVMTQQGVLS PNGSCSTFSA EADGYARAES
VNAVYLKLLD DALRDGDPIR GVIRGTALSA NGKTNGMLLP DAKYQQKTIE EAYKAAGITD
LTQTPFVECH GTGTPVGDPI EVRGVINAFG TEGEHGKPTY IGSHKPNLGH SEGASGINSL
IKAVLAVENG IIPPNIKFNK PNPQIPFDTA RLIVPVEPTP FPACRATRVS INSFGIGGAN
AHLVLDSAAE FLHTYPGVPP PFPAPPPGSH TIWPRMVVVT SSNMASLNQR VHDIKQYLDL
RPRTVLNDVA YTLANRRSHL TYRSFAVVTH SQNEPFEFEK PQISYAKPPA PVFVFTGQGA
QWGGMASDLL RISPVFAESI RTMDAALAKL GPAAPSWTLE KMIAAKDDET KALFDKPEFS
QPLCTAVQVG VLQFMQACGV QHTAVVGHSS GEIAAAYAAG GLTLQEAIVV SYLRGWAVKV
EQAKGTGTKG GMAAVGLGKT EAEKYVCPGV VVACENSPQS VTLSGDEDVL DAALSEISKS
SVFTRRLKVD VAYHSHHMKN VGEVYDTALS PQLAKSKKKL SVPFYSSVTL EKVGNSEIFD
TAYWCKNLKS PVRFNDAVQS IISDNPDKDL VFLEIGPHST LQGPLRQIFQ VAAQNGRFLG
KNFLYIPTLL RNVPAKISLT KAAGHAFSFG IPVNFGILTP PPTPTSKPLT DLPRYPWDRN
VEFWNESRLS VAHRFPKYPR HELLGTRGLE GTDLEPTWRN IIAPNDIPWV QDHVVGSDVI
LPCAGYVSMV GEALRQLSGD DNAGYTLREV EVKSALILPD NRAVEVMTTA RLVRPSTFGE
PGSWYEFSIS SYNGSSWMQL YSAKGRSGAE SGYPAKMPLQ PTHKFSRKVS SEVWYDAFAH
VGLAYGPKFQ GLASLSAVPG EPLGSSTIKT FDEDISKKSS ATYTQHPTTL DCALQLGLFA
STSGLPKRLS AVLPTAIDFV YVKPASNLKS LYTQATFQKN QNKGKVLGGH SCRALDPQTF
ETIIDIQNCR HTHFQIKSKS NSIGNGFDHV GAASLVWRPD INFCKPEVTM KPLPDVYRPS
KVLLEKIVAL CVLHSVDVMT IEKAKVGSND ISFVEPHLKK YIAWLSTAKA EMLSGTGSWS
RLCPEAQHFA SMSLEQRENE FSLVEQQVAA MSSHNSDMGV MMRICRKLAE NMYLLATGKA
NSVEIMFSRT SESLASWYDF LGNLLDFSEY FKLSGHANPN LRVLEIGAGT GASSARVLQA
LVADSNKPRY GEYTFTDVSS GFFEAARDRL KEYPNIKYKV LDISRDPAEQ GFELGSYDLI
VASNVIHATP NLNQTLTNTR ALLRDGGRFY LQEVVGPTNV FGFLAGVFSG WWMGEFDGRP
NAPTVSVDRW HQELIAAGFS GAGDAVLDDD ETLTYLANIV TRAMPVKNQA PEFKTATIIY
EKEKPTFASS LSSSLAANGF GVSWEKLEDF ASSSVTPSVV ISALDLEHPF FVGLTSRKYA
LLTNIILNLS TPLIWLTCPA QVDVENPHYA QIIGLGRNVR NELSKKFVTI ELGSSDTASA
KAVTKIVEDL AVNLTNVSSS SHYDADSEYF VKDGIVYTSR YETLMLDDEL AEQSHERTSV
TLISSEVGSF NKPKWIEESV VLALAANDVE VDVQATSLNY KYHDVMLYSN SLEGSENHIG
VEAAGVVSRV GALVDNIKVG DRVVLIAAGA VSSVKVVNKD LVVKIPDSLD FEQAATLPIS
YLTAIHALSN LKSGQTVLIH SGSGSLGQAA IQVAQMLGAT VFTTAGTEEK ADFITSQFGI
PPSRIFSSCD ISFAYGVMFS TLGKGVDVVF NTLSGELLQA SWGCVSPNGK MINMTRDSEQ
LPASAQNSSR TLISLNMGLM ISERPSEVNL LLNKTLDHFS RGHIKPITIS EVFSAKDVSH
GFSHIQANKH MGRVVLTFNV SESLAAFSSR KKQSIAFSSF KTYLLAGGMG GLGKSIATWM
VEHGARKFIF LSRSAGISEA DKAFITELES QGCYVNAIAS SVADASAVEK AVQSAPSRLG
GIMQLSMVLS DASLSDMTYE QWMIPQGPKV DGTWNLHNAT VDTPLDFFVL FSSISSVAGN
PGQANYSSAG TFIEAFAQYR QRQGLACSVV NIGAVQGVGY ISRHKTVSST ITSMGQSMLQ
EQDVLDSVQV SIQRPFNGCE FSEPVGNDKN GSFLFSGQLV TGLRSTRVTS NADCHVPWKR
DIRTSIVQVD EAIMIEQASA FDSDTSGTAA SNSANDIDAP NTILRDLVRE VSSDTQKLTA
KATMDTLVHN IGRVLCRILL QPEDCLENGV TLMQMGLDSM VGIEVRNWWK RTFPGDISVL
QIINAVTIER LAQMALEALQ KNAQAI
//
