ID A0A0F5EWK9_AVIPA Unreviewed; 860 AA.
AC A0A0F5EWK9;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:SUV40944.1};
GN ORFNames=NCTC10926_03004 {ECO:0000313|EMBL:SUV40944.1};
OS Avibacterium paragallinarum (Haemophilus gallinarum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Avibacterium.
OX NCBI_TaxID=728 {ECO:0000313|EMBL:SUV40944.1, ECO:0000313|Proteomes:UP000254620};
RN [1] {ECO:0000313|EMBL:SUV40944.1, ECO:0000313|Proteomes:UP000254620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10926 {ECO:0000313|EMBL:SUV40944.1,
RC ECO:0000313|Proteomes:UP000254620};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; UFSW01000003; SUV40944.1; -; Genomic_DNA.
DR RefSeq; WP_046098665.1; NZ_VXDA01000004.1.
DR AlphaFoldDB; A0A0F5EWK9; -.
DR STRING; 728.VY92_01765; -.
DR eggNOG; COG0249; Bacteria.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000254620; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 690..706
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 616..623
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 860 AA; 96234 MW; 7BE59A826899BFF1 CRC64;
MGLDDKNNQH TPMMQQYLKL KAENPETLLF YRMGDFYELF YDDAKKAAKL LDISLTKRGK
SAGQLIPMAG VPYHAVEGYL AKLVQLGESV AICEQVGDPT TAKGPVERQI VRIVTPGTIS
DEALLPERQD NLIAAVYQEK EKFGLATLDM TSGRFQISEL NTKESLQAEL QRIQPAELLY
CEDFEDRYLI ENAKGLRRRP IWEFELKTAI EQLNRQFGTQ DLRGFGVEKA IIGLCAAGCL
LQYARETQRT ALPHIQSISL LQNSDNIQLD AATRRNLELT QNLAGGTEHT LAAVLDRCVT
PMGSRLLKRW IHQPIRDRKK LTQRQQSIQQ ILQQDLVAEL QPLLQQVGDM ERILARVALR
SARPRDLTRL RTALEQIPAI QHYLTQKTSS ELTALSNQLA DFSPQLDLLQ RAIIDNPPLL
IRDGGVIATG FNAELDEWRS LSDGATRYLE ELEQREREKT GIDSLKIGFN AVHGYYLQIP
QGQAHKAPIH YVRRQTLKNA ERYIIPELKT YEDKVLKAKG AALALEKQLY DEIFDELLPH
LGALQLASLA LSELDVLTNL AERADSLNYV APQFSDQVGL NIENGRHPVV EQVTKTPFIA
NPVHLNPERH LLIITGPNMG GKSTYMRQTA LITLMAYMGS FVPAEQAIIG PVDRIFTRIG
ASDDLASGRS TFMVEMTEMA NILHQATDHS LVLIDEIGRG TSTYDGLSLA WACAEWLAQK
VRSLTLFATH YFELTVLPEQ LSGVANVHLD AVEHNDTIAF MYAVQEGAAS KSYGLAVAAL
AGVPKSVIKL AKQKLTQLEK LSQKTPHLTT PPAQQMQGEL HLMEAEENQS AVLKMLENLD
PDEMTPKQAL AYLYQLKKMV
//
